Results 71 to 80 of about 340,819 (312)

Kaposi sarcoma [PDF]

Nature Reviews Disease Primers, 2019
Kaposi sarcoma (KS) gained public attention as an AIDS-defining malignancy; its appearance on the skin was a highly stigmatizing sign of HIV infection during the height of the AIDS epidemic. The widespread introduction of effective antiretrovirals to control HIV by restoring immunocompetence reduced the prevalence of AIDS-related KS, although KS does ...
Cesarman, Ethel, Damania, Blossom, Krown, Susan E, Martin, Jeffrey, Bower, Mark, Whitby, Denise   +5 more
openaire   +4 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Lower limb function and quality of life after ILP for soft-tissue sarcoma

World Journal of Surgical Oncology, 2017
Background Isolated limb perfusion with TNF-alpha and melphalan (TM-ILP) in combination with complete tumor resection is an effective treatment option for non-resectable soft-tissue sarcoma of the extremities, with limb salvage rates greater than 80 ...
Lars Erik Podleska, Nevda Kaya, Farhad Farzaliyev, Christoph Pöttgen, Sebastian Bauer, Georg Taeger   +5 more
doaj   +1 more source

SARCOMA OF THE PROSTATE

Annals of Surgery, 1920
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openaire   +4 more sources

Survival of soft tissue sarcoma patients after completing six cycles of first-line anthracycline containing treatment: an EORTC-STBSG database study [PDF]

, 2020
Background Doxorubicin based chemotherapy is standard first line treatment for patients with soft tissue sarcoma. Currently several options to improve survival after doxorubicin based chemotherapy are being studied.
Judson, I., Verschoor, AJ, Gelderblom, H., Toulmonde, M, Marréaud, S, Verschoor, A.J., Judson, I, Toulmonde, M., Wardelmann, E, LeCesne, A., Gelderblom, H, LeCesne, A, Litiere, S., Wardelmann, E., Litière, S, Marreaud, S.   +15 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Risk factors for high anti-HHV-8 antibody titers (≥1:51,200) in black, HIV-1 negative South African cancer patients: a case control study [PDF]

, 2003
Background: Infection with human herpesvirus 8 (HHV-8) is the necessary causal agent in the development of Kaposi's sarcoma (KS). Infection with HIV-1, male gender and older age all increase risk for KS.
Sitas, F., Hale, M., Newton, R., Urban, MI, Wojcicki, J.M., Martin Hale, Bourboulia, D., Newton, R, Bourboulia, D, Wojcicki, JM, Rob Newton, Hale, M, Stein, L., Patel, M, Moosa Patel, Ranjan Sur, Sur, R., Stein, L, Margaret I Urban, Sur, R, Ruff, P, Ruff, P., Lara Stein, Sitas, F ; https://orcid.org/, Janet M Wojcicki, Freddy Sitas, Patel, M., Paul Ruff, Dimitra Bourboulia, Urban, M.I.   +29 more
core   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Increasing Awareness of Soft-Tissue Sarcoma: Podcast of a Patient–HCP Discussion

Oncology and Therapy
Soft-tissue sarcoma is a rare cancer, making up less than 1% of new cancer diagnoses. They comprise tumours of the connective tissue, and as such can arise in any part of the body and can mimic other conditions. In addition, there are over 80 subtypes of
Gillian Faskin, Sam Hackett
doaj   +1 more source