Results 81 to 90 of about 340,819 (312)

Functional outcome of surgical treatment of adults with extremity osteosarcoma after megaprosthetic reconstruction—single-center experience

Journal of Orthopaedic Surgery and Research, 2019
Background Osteosarcoma is the most common primary malignant bone tumor in adults and is usually located in the long bones. Standard treatment consists of perioperative chemotherapy and radical surgical resection.
Tomasz Goryń, Andrzej Pieńkowski, Bartłomiej Szostakowski, Marcin Zdzienicki, Iwona Ługowska, Piotr Rutkowski   +5 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Clear Cell Sarcoma-Like Tumor of the Gastrointestinal Tract, Presenting as a Second Malignancy after Childhood Hepatoblastoma

Case Reports in Medicine, 2014
Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) is a rare malignant neoplasm arising within the wall of the small bowel, stomach, or large bowel, predominantly in children and young adults.
Khin Thway, Ian Judson, Cyril Fisher
doaj   +1 more source

Retroperitoneal Sarcomas

Cancer Control, 2005
The evaluation and treatment of retroperitoneal sarcomas are challenging because the tumors are relatively rare and frequently present with advanced disease in an anatomically complex location.We reviewed the literature on experience in the management of retroperitoneal sarcomas, and we present our own experience in the treatment of these tumors.The ...
T Christopher, Windham, Peter W T, Pisters   +1 more
openaire   +2 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Real-World Efficacy and Safety of Anti-PD-1 Antibody Plus Apatinib and Temozolomide for Advanced Acral Melanoma

Cancer Management and Research
Jiaran Zhang,1,* Huichun Tian,1,* Lili Mao,1 Caili Li,1 Xiaoting Wei,1 Junjie Gu,1 Xuan Wang,1 Li Zhou,2 Bin Lian,1 Bixia Tang,1 Xieqiao Yan,2 Siming Li,2 Chuanliang Cui,1 Zhihong Chi,1 Xinan Sheng,2 Jun Guo,1 Lu Si1 1Department of ...
Zhang J, Tian H, Mao L, Li C, Wei X, Gu J, Wang X, Zhou L, Lian B, Tang B, Yan X, Li S, Cui C, Chi Z, Sheng X, Guo J, Si L   +16 more
doaj  

An innovative staged prosthetic lengthening reconstruction strategy for osteosarcoma-related leg discrepancy

Scientific Reports
Correction of leg length discrepancy (LLD) in skeletally mature patients with osteosarcoma was rarely reported and quite challenging. This study aimed to propose a treatment strategy of staged lengthening and reconstruction with a standard static ...
Hairong Xu, Yuan Li, Feng Yu, Weifeng Liu, Lin Hao, Qing Zhang, Xiaohui Niu   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Limb-Salvage Reconstruction of the Proximal Humerus Using Patient-Specific 3D-Printed PEEK Implants: A Midterm Clinical Study

Bioengineering
Background: Reconstruction of the proximal humerus after wide tumor resection is technically demanding, and traditional methods such as allograft–prosthetic composites, reverse shoulder arthroplasty, and metal implants are limited by graft unavailability,
Tran Duc Thanh, Le Duc Huy, Nguyen Duc Trung, Luong Nhat Anh, Vu Duc Thang, Luu Huu Phuc, Le The Hung, Vo Sy Quyen Nang, Pham Trung Hieu, Nguyen Tran Quang Sang, Dang Minh Quang, Tran Trung Dung   +11 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source