Results 71 to 80 of about 698,336 (388)

An update on the management of sporadic desmoid-type fibromatosis: a European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG)

Annals of Oncology, 2017
Desmoid-type fibromatosis is a rare and locally aggressive monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course.
B. Kasper, C. Baumgarten, J. García, S. Bonvalot, R. Haas, F. Haller, P. Hohenberger, N. Penel, C. Messiou, W. V. D. van der Graaf, A. Gronchi, S J Y F P H R M V R I C K A L H J P S E C K E M Bauer Blay van Coevorden Dileo Dürr Fiore Grünwald, S. Bauer, J. Blay, F. van Coevorden, P. Dileo, H. Dürr, M. Fiore, V. Grünwald, R. Jones, I. Judson, C. Kettelhack, K. Kopeckova, A. Lazar, L. Lindner, J. Martín-Broto, P. Rutkowski, S. Stacchiotti, E. Stoeckle, C. Valverde, K. Verhoef, E. Wardelmann, M. Wartenberg   +32 more
semanticscholar   +1 more source

The reverse protraction factor in the induction of bone sarcomas in radium-224 patients [PDF]

, 1990
More than 50 bone sarcomas have occurred among a collective of about 800 patients who had been injected in Germany after World War II with large activities of radium-224 for the intended treatment of bone tuberculosis and ankylosing spondylitis.^In an ...
Chmelevsky, D., Kellerer, Albrecht M., Mays, C. W., Spiess, H.   +3 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma

American Journal of Surgical Pathology, 2018
Tropomyosin receptor kinase (Trk) inhibitors have shown high response rates in patients with tumors harboring NTRK fusions. We identified 4 NTRK fusion-positive uterine sarcomas that should be distinguished from leiomyosarcoma and undifferentiated ...
S. Chiang, P. Cotzia, D. Hyman, A. Drilon, W. Tap, Lei Zhang, J. Hechtman, D. Frosina, A. Jungbluth, R. Murali, Kay J. Park, R. Soslow, E. Oliva, A. Iafrate, R. Benayed, M. Ladanyi, C. Antonescu   +16 more
semanticscholar   +1 more source

New strategies in soft tissue sarcoma treatment

Journal of Hematology & Oncology
Soft tissue sarcomas (STS) have long been a formidable challenge in oncology, partly because of their rarity and diversity, which complicates large-scale studies and slows the advent of new treatments.
Mariella Spalato-Ceruso, Nathan El Ghazzi, Antoine Italiano   +2 more
doaj   +1 more source

Exploring the Importance of Single Nucleotide Polymorphisms of HSPA9 in DNA of Sarcoma Patients [PDF]

, 2013
The aim of this project was to identify genetic variants that may influence the risk and progression of sarcoma through targeted genotyping of HSPA9 gene. It is important to look at genetic variants in DNA samples because if a variant is determined to be
Hebert, Christine M
core   +1 more source

Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model. [PDF]

, 2016
A patient with high grade undifferentiated pleomorphic soft-tissue sarcoma from a striated muscle was grown orthotopically in the right biceps femoris muscle of mice to establish a patient-derived orthotopic xenograft (PDOX) model.
Bouvet, Michael, Chawla, Sant, Chishima, Takashi, DeLong, Jonathan, Deng, Samantha, Eilber, Fritz C, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Matsuyama, Ryusei, Murakami, Takashi, Quan, Cuong, Reynoso, Jose, Russell, Tara, Singh, Arun, Tanaka, Kuniya, Zhang, Nan, Zhang, Yong, Zhao, Ming   +18 more
core   +3 more sources

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Setting the international research agenda for sarcomas with patients and carers: results of phase II of the Sarcoma Patient Advocacy Global Network (SPAGN) priority setting partnership

BMC Cancer
Background Typically, researchers and clinicians determine the agenda in sarcoma research. However, patient involvement can have a meaningful impact on research.
E. Roets, K. Schuster, S. Bickley, M. Wartenberg, O. Gonzato, N. Fernandez, B. Kasper, K. Pilgermann, R. Wilson, N. Steeghs, W. T. A. van der Graaf, G. van Oortmerssen, O. Husson   +12 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source