Results 221 to 230 of about 17,660 (277)

Adaptations in biceps femoris long-head muscle-tendon mechanics during the Nordic hamstring exercise in response to 9 weeks of training. [PDF]

J Sport Health Sci
Andrews MH, Pai S A, Gurchiek RD, Hodges PW, Lichtwark GA, Delp SL, Pincheira PA.   +6 more
europepmc   +1 more source

RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation. [PDF]

Circ Res
Froese N, Shymotiuk I, Froese A, Polten F, Jablinski J, Scholz T, Korf-Klingebiel M, Werlein C, Galuppo P, Gigina A, Wihler K, Schneider J, Erschow S, Heimerl M, Szaroszyk M, Hegermann J, Wrede C, Schweitzer T, Pich A, Geffers R, Ricke-Hoch M, Kühnel MP, Jonigk DD, Wende AR, Abel ED, Nikolaev VO, Wollert KC, Bauersachs J, Riehle C.   +28 more
europepmc   +1 more source

Genotype‐Dependent Effects of Mechanical Stretch and GATA4‐Targeted Compound 3i‐1262 in Cardiomyopathy Patient–Derived hiPSC‐Cardiomyocytes

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Genetic hypertrophic and dilated cardiomyopathies (HCM and DCM, respectively) are characterised by structural and functional abnormalities that can lead to heart failure. However, current therapies mainly reduce symptoms. Patient‐derived human induced pluripotent stem cell (hiPSC)–derived cardiomyocytes provide a valuable platform to study ...
Saana Pohjavaara, Sini M. Kinnunen, Heikki Ruskoaho, Katriina Aalto‐Setälä, Mika J. Välimäki, Virpi Talman   +5 more
wiley   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, Volume 293, Issue 18, Page 5645-5663, September 2026.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Glycogenin-1 deficiency: a case report and review of the literature. [PDF]

Front Genet
Molitierno N, Velardo D, Salvucci G, Abati E, Tumminello G, Ripolone M, Zanotti S, Napoli L, Ciscato P, Sciacco M, Comi GP, Corti S, Ronchi D.   +12 more
europepmc   +1 more source

Epigenetic Changes Associated With a Phenotypic Transition in Namibian Cheetahs

Molecular Ecology, Volume 35, Issue 17, September 2026.
ABSTRACT In populations with low genetic diversity, the capacity to adapt to environmental change is limited. While epigenetic mechanisms can generate phenotypic plasticity, their role in mediating adaptive life‐history transitions in the wild is largely unknown.
Colin Vullioud, Diana Geweiler, Joerg Melzheimer, Sonja Heinrich, Jörns Fickel, Bettina Wachter, Alexandra Weyrich   +6 more
wiley   +1 more source

Scarless Regeneration Following Third‐Degree Burns in the Japanese Fire‐Bellied Newt (Cynops pyrrhogaster)

Wound Repair and Regeneration, Volume 34, Issue 5, September/October 2026.
ABSTRACT Deep burn injuries in mammals typically heal with fibrosis and scar formation. Although the Japanese fire‐bellied newt (Cynops pyrrhogaster) exhibits scarless skin regeneration after injury, whether this capacity is maintained after third‐degree burn remains unclear.
Ikkei Takashimizu, Kengo Fujita, Fubito Toyama, Chikafumi Chiba, Shunsuke Yuzuriha   +4 more
wiley   +1 more source

Isometric training at longer muscle–tendon complex lengths: A potential countermeasure to impaired neuro‐muscle–tendon function during space travel

Experimental Physiology, Volume 111, Issue 9, Page 4041-4053, 1 September 2026.
Abstract Manned space exploration to distant destinations, including Mars, continues to be an aspiration of humankind. Space travel does, however, present many challenges to the body, amongst which adaptation to microgravity is perhaps the largest. For instance, both short and long manned spaceflight missions have shown substantial deleterious effects ...
Gerard McMahon, Andy Sanderson, Hans Degens   +2 more
wiley   +1 more source

Integrative simulation analysis of myocardial ischaemia–reperfusion injury

The Journal of Physiology, Volume 604, Issue 18, Page 7640-7662, 15 September 2026.
Abstract figure legend A comprehensive mathematical model of ventricular myocyte was developed to gain insights into the mechanisms underlying cardiac ischaemia–reperfusion injury. The model integrates excitation–contraction (E–C) coupling, cytosolic and mitochondrial pH regulation, pH dependence of major E–C coupling components and cellular energy ...
Takao Shimayoshi, Ayako Takeuchi, Satoshi Matsuoka   +2 more
wiley   +1 more source

Piperine disrupts the OFF state of the resting thick filament of rat skeletal muscle, enhancing dynamic contractility in a fibre‐type‐dependent manner

The Journal of Physiology, Volume 604, Issue 18, Page 7739-7771, 15 September 2026.
Abstract figure legend We investigated the effects of piperine on (1) the structure of the resting thick filament and (2) dynamic contractility in fibres and intact slow (soleus) and fast (extensor digitorum longus, EDL) rat muscles, respectively. The structure of the resting thick filament was assessed pre‐ and post‐piperine incubation using small ...
Daniel Z. Kruse, Jon Herskind, Michel N. Kuehn, Annika J. Klotz, Anthony L. Hessel, Kristian Overgaard   +5 more
wiley   +1 more source