Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues. [PDF]
Silberman E +7 more
europepmc +1 more source
Reviewer #2 (Public review): Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes [PDF]
Dylan A Valencia +7 more
openalex +1 more source
Architecture of lower leg muscles in children: Reference curves and potential mechanisms of growth
Muscle architecture (physiological cross‐sectional area, fascicle lengths and pennation angle) was measured from multimodal MRI scans of the lower legs of 197 children aged ≤15 years. We showed that lower leg muscle volumes (product of PCSA and fascicle length) increase primarily through increases in PCSA (transverse growth) rather than increases in ...
Brian V. Y. Chow +12 more
wiley +1 more source
Quantifying HiPSC-CM structural organization at scale with deep learning-enhanced SarcGraph. [PDF]
Mohammadzadeh S, Lejeune E.
europepmc +1 more source
Novel MYL1 Intron Variant With Expanded Phenotype
ABSTRACT Congenital myopathy‐14 (CMYO14) is an ultrarare autosomal recessive disorder caused by biallelic variants in MYL1, with only four patients reported to date. We describe what is likely the fifth reported patient, a neonate with severe hypotonia, respiratory insufficiency, and skeletal anomalies showing distinct histological changes of skeletal ...
Maria Barington +7 more
wiley +1 more source
Reduced Expression of MTSS1 Increases Sarcomere Number and Improves Contractility in Select Forms of Monogenic DCM. [PDF]
Kleppe H +14 more
europepmc +1 more source
Announcement: Review Focus on The Cardiac Myocyte Sarcomere [PDF]
R. John Solaro, Pieter P. de Tombe
openalex +1 more source
ABSTRACT Peripartum cardiomyopathy (PPCM) is defined as the onset of left ventricular systolic dysfunction either during pregnancy or up to 5 months after delivery, without any other known cause of heart failure. The exact pathogenesis of this disease is unknown, and its prognosis remains poorly understood.
Muhammad Ibrahim Shah +4 more
wiley +1 more source
Titin's P-zone domains A164-167 are essential for thick filament structural arrangement. [PDF]
Hoover Browne C +10 more
europepmc +1 more source
Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley +1 more source

