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Cofilin-2 Controls Actin Filament Length in Muscle Sarcomeres [PDF]
Developmental Cell, 2014 International audienceADF/cofilins drive cytoskeletal dynamics by promoting the disassembly of "aged" ADP-actin filaments. Mammals express several ADF/cofilin isoforms, but their specific biochemical activities and cellular functions have not been ...
Pekka Lappalainen, Alphee Michelot
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Effects of strain on contractile force and number of sarcomeres in series of Xenopus laevis single muscle fibres during long-term culture [PDF]
Journal of Muscle Research and Cell Motility, 2004 The aim of the present study is to test whether mechanical strain uniquely regulates muscle fibre atrophy/hypertrophy and adaptation of the number of sarcomeres in series within mature muscle fibres in vitro.
Richard Jaspers +1 more
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The Sarcomere and Sarcomerogenesis
2008Striated muscle owes its name to the microscopic appearance, caused by the longitudinal alignment of thousands of highly ordered contractile units, the sarcomeres. The assembly (and disassembly) of these multiprotein complexes (sarcomere assembly or sarcomerogenesis) follows ordered pathways, which are regulated on the transcriptional, translational ...
Ehler, E, Gautel, M
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Mathematical Modeling of the Dynamic Mechanical Behavior of Neighboring Sarcomeres in Actin Stress Fibers [PDF]
Cellular and Molecular Bioengineering, 2014 pre-printActin stress fibers (SFs) in live cells consist of series of dynamic individual sarcomeric units. Within a group of consecutive SF sarcomeres, individual sarcomeres can spontaneously shorten or lengthen without changing the overall length of ...
Beckerle, Mary C. +1 more
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On the isometric equation of the sarcomere
Basic Research in Cardiology, 1974A model of the sarcomere is described, which is based upon (a) the sliding filament theory ofHuxley, (b) the ultrastructure of the sarcomere, (c) the biochemical mechanisms responsible for mechanical coupling and uncoupling of myosin and actin, (d) the constancy of the volume of the sarcomere and (e) a statistical analysis of random forces acting on ...
P J, Lewi, W K, Schaper, L M, Gijpen
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The Cardiac Sarcomere and Cell Cycle
Current Cardiology Reports, 2022The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor limiting adult human cardiomyocyte proliferation through incompletely ...
Anthony M. Pettinato +2 more
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Redox Signaling and Cardiac Sarcomeres [PDF]
Journal of Biological Chemistry, 2011 Oxidative stress is common in many clinically important cardiac disorders, including ischemia/reperfusion, diabetes, and hypertensive heart disease. Oxidative stress leads to derangements in pump function due to changes in the expression or function of proteins that regulate intracellular Ca(2+) homeostasis.
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Dysfunctional sarcomeric relaxation in the heart
Current Opinion in Physiology, 2022Since cardiac relaxation is commonly impaired in heart failure caused by many different etiologies, identifying druggable targets is a common goal. While many factors contribute to cardiac relaxation, this review focuses on sarcomeric relaxation and dysfunction.
Walter E, Knight, Kathleen C, Woulfe
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Targeting the sarcomere in inherited cardiomyopathies
Nature Reviews Cardiology, 2022Variants in >12 genes encoding sarcomeric proteins can cause various cardiomyopathies. The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Current therapeutics do not target the root causes of these diseases, but attempt to prevent disease progression and/or to manage symptoms.
Sarah J. Lehman +2 more
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Atomistic Simulations of Sarcomere Proteins
2023Concerted atomic motions are requisite for sarcomere protein function and may become disrupted in HCM pathologies. Computational approaches such as molecular dynamics simulation can resolve such dynamics with unrivalled spatial and temporal resolution.
Matthew Carter, Childers +1 more
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