Results 131 to 140 of about 11,481 (144)
Effect of muscle tension during tendon transfer on sarcomerogenesis in a rabbit model
Journal of Hand Surgery, 2000 Sarcomere number change was investigated in an animal model of tendon transfer. In 9 adult New Zealand white rabbits, the flexor digitorum longus muscle was cut distally and transferred and woven into the tibialis anterior tendon. Ankles were then immobilized for 3 weeks in 75 degrees flexion.
Eva Pontén +2 more
exaly +4 more sources
Journal of Biomechanics, 2020 It has been suggested that eccentric contraction (EC) is associated with increases in serially-arranged sarcomeres (sarcomerogenesis), while concentric contraction (CC) has been associated with serial sarcomeres decrease. Sarcomerogenesis following EC is thought to be a protective muscle adaptation, preventing muscle injury in future eccentric exercise
Andrea Carvalho +2 more
exaly +3 more sources
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The role of Z substance in sarcomerogenesis
Journal of Molecular and Cellular Cardiology, 1973Marianne J Legato
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Muscle Giants: Molecular Scaffolds in Sarcomerogenesis [PDF]
Physiological Reviews, 2009 Myofibrillogenesis in striated muscles is a highly complex process that depends on the coordinated assembly and integration of a large number of contractile, cytoskeletal, and signaling proteins into regular arrays, the sarcomeres. It is also associated with the stereotypical assembly of the sarcoplasmic reticulum and the transverse tubules around each
Robert J Bloch +2 more
exaly +3 more sources
Sarcomerogenesis in human myocardium
Journal of Molecular and Cellular Cardiology, 1970Abstract Myocardial tissue obtained at the time of open heart surgery from 19 patients, rat ventricular cells grown in tissue culture and atrial and ventricular tissue from newborn puppies were examined with the electron microscope in order to delineate the function of the sarcomeric Z band.
Marianne J Legato
exaly +3 more sources
Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth [PDF]
Cell Reports, 2020 Sarcomeres, the fundamental contractile units of muscles, are conserved structures composed of actin thin filaments and myosin thick filaments. How sarcomeres are formed and maintained is not well understood. Here, we show that knockdown of Drosophila cofilin (DmCFL), an actin depolymerizing factor, disrupts both sarcomere structure and muscle function.
David B Soffar +2 more
exaly +3 more sources
Physiology, 2023
During natural aging, muscles atrophy, which is partly accounted for by a loss of sarcomeres in series. Serial sarcomere number (SSN) is associated with aspects of muscle mechanical function including the force-length and force-velocity-power relationships; hence, the age-related loss of SSN contributes to declining performance.
Avery Hinks +3 more
openaire +2 more sources
During natural aging, muscles atrophy, which is partly accounted for by a loss of sarcomeres in series. Serial sarcomere number (SSN) is associated with aspects of muscle mechanical function including the force-length and force-velocity-power relationships; hence, the age-related loss of SSN contributes to declining performance.
Avery Hinks +3 more
openaire +2 more sources
Serial sarcomerogenesis does not contribute to the initial repeated bout effect in skeletal muscle
Journal of BiomechanicsNeuromuscular function is impaired following an unaccustomed bout of eccentric exercise. However, through the repeated bout effect (RBE), the muscle is protected from impaired neuromuscular function following a subsequent bout of eccentric exercise. It has been speculated that the addition of sarcomeres in series (sarcomerogenesis) contributes to the ...
Avery Hinks, Geoffrey A Power
exaly +3 more sources
Journal of Cell Science, 2000
ABSTRACT An essential role of titin as a molecular ruler in sarcomerogenesis has been frequently discussed. In this study, we tested the hypothesis that the expression of titin is a prerequisite for thick filament incorporation into sarcomeres by using an antisense oligonucleotide approach to interfere with titin translation in the de ...
Sawa Kostin +2 more
exaly +3 more sources
ABSTRACT An essential role of titin as a molecular ruler in sarcomerogenesis has been frequently discussed. In this study, we tested the hypothesis that the expression of titin is a prerequisite for thick filament incorporation into sarcomeres by using an antisense oligonucleotide approach to interfere with titin translation in the de ...
Sawa Kostin +2 more
exaly +3 more sources
Biochemical Journal, 2013
skNAC (skeletal and heart muscle specific variant of nascent polypeptide-associated complex α) is a skeletal and heart muscle-specific protein known to be involved in the regulation of sarcomerogenesis. The respective mechanism, however, is largely unknown. In the present paper, we demonstrate that skNAC regulates calpain activity.
Janine, Berkholz +2 more
openaire +2 more sources
skNAC (skeletal and heart muscle specific variant of nascent polypeptide-associated complex α) is a skeletal and heart muscle-specific protein known to be involved in the regulation of sarcomerogenesis. The respective mechanism, however, is largely unknown. In the present paper, we demonstrate that skNAC regulates calpain activity.
Janine, Berkholz +2 more
openaire +2 more sources