Results 11 to 20 of about 21,252 (294)

Whole-Transcriptome Analysis of Repeated Low-Level Sarin-Exposed Rat Hippocampus and Identification of Cerna Networks to Investigate the Mechanism of Sarin-Induced Cognitive Impairment

Biology, 2023
Sarin is a potent organophosphorus nerve agent that causes cognitive dysfunction, but its underlying molecular mechanisms are poorly understood. In this study, a rat model of repeated low-level sarin exposure was established using the subcutaneous ...
Jingjing Shi, Dongxin Liu, Qian Jin, Xuejun Chen, Ruihua Zhang, Tong Shi, Siqing Zhu, Yi Zhang, Xingxing Zong, Chen Wang, Liqin Li   +10 more
doaj   +2 more sources

The Impairment of Spatial Memory Following Low-Level Sarin Inhalation Exposure and Antidotal Treatment in Rats

Acta Medica, 2002
1. To study the influence of antidotes on low-level sarin-induced impairment of cognitive functions, the rats were exposed to three various low concentrations of sarin (LEVEL 1–3) for 60 minutes in the inhalation chamber.
Jiří Kassa, Gabriela Krejčová, Josef Vachek   +2 more
doaj   +2 more sources

Effect of Atropine and the Oxime HI-6 on Low-Level Sarin-Induced Alteration of Performance of Rats in a T-Maze

Acta Medica, 2002
1. To study the influence of antidotes on low-level sarin-induced alteration of cognitive functions, male albino Wistar rats were exposed to three various low concentrations of sarin for 60 minutes in the inhalation chamber.
Gabriela Krejčová, Jiří Kassa, Josef Vachek   +2 more
doaj   +2 more sources

Three in one fluorescent sensing and imaging of chemical warfare agents [PDF]

Nature Communications
Chemical warfare agents (CWAs) pose severe global threats due to their historical role in mass casualties and ongoing misuse, particularly blister, nerve, and blood agents.
Junhong Liu, Yin Gong, Linwen Tan, Jinfeng Cen, Mo Li, Chuyu Wang, Xuan Zhao, Mingxue Sun, Qitao Tan, Wen-Qi Meng   +9 more
doaj   +2 more sources

Antidote administration in mice exposed to sarin resulted in brainwave stabilization without cognitive protection

Neuroscience Research
Resurgence of sarin use in the Syrian conflict demonstrates that chemical weapons are a vivid threat. Like other organophosphate compounds, sarin inhibits acetylcholinesterase resulting in cholinergic crisis.
Mélanie Lagadec, Pauline Thiebot, Isabelle Malissin, Alexandre Champault, Julie Somkhit, Julie Knoertzer, Assia Belkebir, Bruno Megarbane, Karine Thibault, Gregory Dal Bo   +9 more
doaj   +2 more sources

Study on the Degradation Effect of Three Organophosphorus Hydrolase Mutant on Sarin [PDF]

E3S Web of Conferences, 2021
Organophosphorus hydrolase can effectively degrade organic phosphorus compounds such as sarin. In this study, we constructed a recombinant Bacillus subtilis mutant expressing organophosphorus hydrolase, measured the effect of the mutant on the ...
Gu Qiamin, Zhao Chuanxin, Xi Hailing, Liu Min, Chen Gaoyun   +4 more
doaj   +1 more source

Chemical Weapons in the Iran-Iraq War (1980-1988) Iraq Preparing for Chemical War

Вестник войск РХБ защиты, 2023
The Iraqis became the first nation to use chemical weapons on the modern battlefield during the IranIraq War (1980-1988). There are no general reviews and research available on this issue in Russian.
M. V. Supotnitskiy, N. I. Shilo, V. A. Kovtun   +2 more
doaj   +1 more source

Monitoring Exposure to Five Chemical Warfare Agents Using the Dried Urine Spot Technique and Liquid Chromatography-Mass Spectrometry/Mass Spectrometry—In Vivo Determination of Sarin Metabolite in Mice

Molecules, 2023
Dried urine spot (DUS) is a micro-sample collection technique, known for its advantages in handling, storage and shipping. It also uses only a small volume of urine, an essential consideration in working with small animals, or in acute medical situations.
Lilach Yishai Aviram, Shai Dagan, Ariel Hindi, Shira Chapman, Rellie Gez, Eyal Drug   +5 more
doaj   +1 more source

Assessing the Clinical Features and Blood Biochemistries of Acute Organophosphorus Chemical Warfare Agents in Iranian Veterans

International Journal of Medical Toxicology and Forensic Medicine, 2021
Background: Nerve Agents (NAs) are a chemical weapons, and their use is prohibited. They were used for numerous-times in the warfare of Iraq against Iran.
khosrow Agin , Babak Mostafazadeh
doaj   +1 more source

The Long Term Influence of Low-Level Sarin Exposure on Behavioral and Neurophysiological Functions in Rats

Acta Medica, 2001
1. Long term effects of low doses of highly toxic organophosphorus agent sarin on behavioral and neurophysiological functions were studied in rats exposed to sarin by inhalation.
Jiří Kassa, Marie Koupilová, Josef Herink, Josef Vachek   +3 more
doaj   +1 more source