Results 71 to 80 of about 10,552 (197)

Ornithine-derived oligomers and dendrimers for in vitro delivery of DNA and ex vivo transfection of skin cells via saRNA.

Journal of materials chemistry. B, 2020
Gene therapies are undergoing a renaissance, primarily due to their potential for applications in vaccination for infectious diseases and cancers. Although the biology of these technologies is rapidly evolving, delivery strategies need to be improved to ...
Francesca Saviano, Tatiana Lovato, A. Russo, G. Russo, Clément R. Bouton, R. Shattock, C. Alexander, F. Quaglia, A. Blakney, Pratik Gurnani, Claudia Conte   +10 more
semanticscholar   +1 more source

Anaemia Among Mother–Child Dyads in India: Trends, Drivers, and Future Projections

Maternal &Child Nutrition, EarlyView.
ABSTRACT Anaemia among mothers and their children is a widespread public health challenge with profound consequences for individuals and societies. While anaemia has been studied separately in women and children, there remains a literature gap examining anaemia in mother‐child dyads, limiting insights on interventions that may simultaneously address ...
Sarang Pedgaonker, Trupti Meher, Monali Gupta, Suman Chakrabarti, Phuong Hong Nguyen, Shri Kant Singh, Laxmi Kant Dwivedi, Aditi, Samuel Scott   +8 more
wiley   +1 more source

Upregulation of LHPP by saRNA inhibited hepatocellular cancer cell proliferation and xenograft tumor growth

PLoS ONE
Hepatocellular carcinoma (HCC) is the most common primary liver cancer worldwide and no pharmacological treatment is available that can achieve complete remission of HCC.
Chuan-Qian Bi, Tao Kang, Yukang Qian, Moorim Kang, Xuhui Zeng, Long-Cheng Li   +5 more
semanticscholar   +1 more source

Occurrence and distribution of sarcoptic mange in wild Neotropical canids

Medical and Veterinary Entomology, EarlyView.
Sarcoptic mange affects most Neotropical canid species across multiple countries. It represents a widespread yet largely overlooked conservation threat with potential for cross‐species transmission. Coordinated monitoring and management efforts are needed to understand and mitigate its impacts. Abstract Sarcoptic mange, a contagious skin disease caused
Luan de Jesus Matos de Brito, Guilherme S. T. Garbino   +1 more
wiley   +1 more source

Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines

Molecular Therapy: Nucleic Acids, 2023
To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccine ...
John S. Tregoning, David C. Stirling, Ziyin Wang, Katie E. Flight, Jonathan C. Brown, Anna K. Blakney, Paul F. McKay, Robert F. Cunliffe, Valarmathy Murugaiah, Christopher B. Fox, Mitchell Beattie, Ying K. Tam, Cecilia Johansson, Robin J. Shattock   +13 more
doaj   +1 more source

The Sixth Scroll: The Ritualization of Israel's Declaration of Independence

Nations and Nationalism, EarlyView.
ABSTRACT This article examines the ritualization of Israel's Declaration of Independence (2011–2025) as part of broader efforts by Israeli Jewish renewal organizations to craft a national counter‐narrative. It argues that reframing the Declaration as a quasi‐sacred text—situated within the Jewish traditional corpus and recited with Biblical ...
Adi Sherzer
wiley   +1 more source

Biomaterial‐Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation

Small, Volume 22, Issue 45, 13 August 2026.
Biomaterial‐integrated electroporation establishes a programmable therapeutic interface that coordinates electric‐field modulation, transient or irreversible membrane permeabilization, cargo stabilization, and immune remodeling. This Review highlights how nanocarriers, hydrogels, and bioelectronic interfaces expand electroporation from conventional ...
Binbin Ji, Zhuozhuo Wu, Yuyue Jiang, Xiaoyu Liu, Jingfeng Li, Fengkuo Xu, Chaojie Li, Qungang Shan, Ziyin Wang, Junhao Wang, Wei Huang, Yaping Zhuang, Wenguo Cui, Zhongmin Wang   +13 more
wiley   +1 more source

Self-Amplifying RNA: Advantages and Challenges of a Versatile Platform for Vaccine Development

Viruses
Self-amplifying RNA is synthetic nucleic acid engineered to replicate within cells without generating viral particles. Derived from alphavirus genomes, saRNA retains the non-structural elements essential for replication while replacing the structural ...
Thomas Vallet, Marco Vignuzzi
doaj   +1 more source

“Feeling out of place”: A mixed methods investigation of the impostor phenomenon among BIPOC and LGBTQ STEM college students

Analyses of Social Issues and Public Policy, Volume 26, Issue 2, August 2026.
Abstract This mixed‐methods study examines the experience of the impostor phenomenon in a racially/ethnically and sexually diverse sample of undergraduates in majors related to science, technology, engineering, and math (STEM). Guided by an intersectionality framework, we examined whether experiences of the impostor phenomenon differ at the ...
Richard Chang, Diana R. Beltran, Gloria Wong‐Padoongpatt, Rachael D. Robnett   +3 more
wiley   +1 more source

Beyond the rainbow: Exploring the role of pride and ally flags on perceptions of LGBTQIA+ allyship in STEM

Analyses of Social Issues and Public Policy, Volume 26, Issue 2, August 2026.
Abstract Lesbian, gay, bisexual, transgender, queer or questioning, intersex, and/or asexual (LGBTQIA+) individuals are critically underrepresented in science, technology, engineering, and math (STEM) workplaces and often face negative workplace experiences, such as social isolation and pressures to conceal their LGBTQIA+ identity.
Charlotte E. Moser, Emily J. Brown, Tiffany A. Ito   +2 more
wiley   +1 more source