Results 191 to 200 of about 1,600,173 (280)

Continuance intention to use mobile learning among college students: integrating quality factors and the expectation confirmation model. [PDF]

Sci Rep
Qiu X, Wu J, Li H.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Concepts and Structure for a “Digital Library of an Astronomer”

Open Astronomy, 2000
Sat Lyudmila
doaj   +1 more source

Cross-cohort federated learning for pediatric abdominal adipose tissue segmentation and quantification using free-breathing 3D MRI. [PDF]

Radiol Adv
Zhang W, Kafali SG, Adamos T, Kuwahara K, Dong A, Li J, Shih SF, Delgado-Esbenshade T, Chowdhury S, Loong S, Moretz J, Barnes SR, Li Z, Ghahremani S, Calkins KL, Wu HH.   +15 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Human-induced temperature rise is driving Africa towards drought-prone climatic conditions. [PDF]

Sci Rep
Swain B, Vountas M, Song R, Singh A, Hari V, Saharwardi MS, Nikumbh A, Deroubaix A, Shende P, Lelli L, Alawode R, Gunthe SS.   +11 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

The Effect of Subcutaneous Fat Tissue Length and Area on Postoperative Wound Drainage in Patients Undergoing Hemiarthroplasty for Femoral Neck Fracture. [PDF]

Arthroplast Today
Önüt M, Bingöl O, Özdemir G, Savaş MF, Yağbasan B, Kılıç E, Özkaya UE.   +6 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Diabetes Alters microRNA Expression in Epicardial and Subcutaneous Adipose Tissue from Patients Undergoing Elective Cardiac Surgery. [PDF]

Cells
Santos D, Canotilho A, Coutinho G, Prieto D, Antunes P, Antunes M, Moreira AFL, Falcão-Pires I, Carvalho E, Dalgaard LT.   +9 more
europepmc   +1 more source