Results 91 to 100 of about 53,205 (302)

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Effect of 360His mutation in apolipoprotein A-IV on plasma HDL-cholesterol response to dietary fat

Journal of Lipid Research, 1997
In order to determine whether genetic variability of apolipoprotein (apo) A-IV is responsible for the improvement in lipid profile when dietary saturated fats are replaced by carbohydrates or monounsaturated fats, 41 healthy male subjects were studied ...
S Jansen, J Lopez-Miranda, J M Ordovas, J L Zambrana, C Marin, M A Ostos, P Castro, R McPherson, F Lopez Segura, A Blanco, J A Jimenez Pereperez, F Perez-Jimenez   +11 more
doaj   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease

Nutrition & Metabolism, 2005
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily strikes the elderly. Studies in both humans and animal models have linked the consumption of cholesterol and saturated fats with amyloid-β (Aβ) deposition and ...
Van Leuven Fred, Wera Stefaan, Van der Auwera Ingrid, Henderson Samuel T   +3 more
doaj   +1 more source

Dual‐Physical‐Field Nanocatalysis: Injectable Hydrogel Enables Piezo‐Photothermal Synergy for Breast Cancer Therapy

Advanced Science, EarlyView.
ABSTRACT Piezocatalytic therapy (PCT) harnesses mechanical energy to generate tumor‐lethal reactive oxygen species (ROS), but its efficacy is limited by rapid electron‐hole recombination and poor intratumoral retention. To overcome these limitations, we engineered heterostructured BiOCl@CuO nanosheets embedded in an injectable, conductive ...
Can Tian, Shihan Xiao, Xuan Chen, Danni Zhang, Zizhen Liu, Jing Wang, Ning Xie, Wei Li   +7 more
wiley   +1 more source

Cardiovascular Disease and the Dietary Consumption of Saturated Fats: A Review of the Strength of the Literature and Evidence

, 2016
Introduction: Dietary guidelines suggest the reduction of saturated fat intake due to its perceived association with cardiovascular disease. However ambiguity remains in the literature regarding this association. This review aims to evaluate the strength
Lovell, D, Eagles, A
core   +1 more source

Plasma phospholipid fatty acid concentration and incident coronary heart disease in men and women: the EPIC-Norfolk prospective study.

PLoS Medicine, 2012
BackgroundThe lack of association found in several cohort studies between dietary saturated fat and coronary heart disease (CHD) risk has renewed debate over the link between dietary fats and CHD.Methods and findingsWe assessed the relationship between ...
Kay-Tee Khaw, Marlin D Friesen, Elio Riboli, Robert Luben, Nicholas Wareham   +4 more
doaj   +1 more source

Substituting dietary monounsaturated fat for saturated fat lowers inflammasome activation observed on a high saturated fat diet

The FASEB Journal, 2013
Altered lipid homeostasis (obesity) is linked to inflammation and defective insulin signaling. In the presence of palmitic acid (PA), but not oleic acid (OA), lipopolysaccharide (LPS)‐stimulated macrophages activate the NLRP3 inflammasome, secreting augmented levels of Interleukin (IL)‐1β and IL‐18 (Nat Immunol12:408). We hypothesized that lowering the
Craig Lawrence Kien, Karen I. Crain, Janice Y. Bunn, Naomi K. Fukagawa, Matthew E. Poynter   +4 more
openaire   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Saturated fats, dairy foods and cardiovascular health: No longer a curious paradox? [PDF]

Nutr Bull, 2022
Givens DI.
europepmc   +1 more source