Results 101 to 110 of about 7,557 (161)

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor

Marine Drugs, 2019
Voltage-gated sodium channels (NaVs) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) NaV subtype with saxitoxin (STX),
Kanna Adachi, Hayate Ishizuka, Minami Odagi, Kazuo Nagasawa   +3 more
doaj   +1 more source

Early developmental toxicity of saxitoxin on medaka (Oryzias melastigma) embryos

, 2014
Saxitoxin (STX) is the most potent paralytic shellfish poisoning toxin in crustaceans and molluscs, and is known to cause intoxication to humans and marine animals due to its neurotoxicity.
Wang, Mingfu, Cheng, Jinping, Chan, Leo Lai, Tian, Li, Lam, Paul Kwan Sing, Chen, Xueping, Mak, Yim Ling, Cheng, Shuk Han   +7 more
core   +1 more source

Preliminary assessment of the performance of oyster shells and chitin materials as adsorbents in the removal of saxitoxin in aqueous solutions

Chemistry Central Journal, 2012
Background This study evaluated the adsorption capacity of the natural materials chitin and oyster shell powder (OSP) in the removal of saxitoxin (STX) from water.
Melegari Silvia P, Matias William G
doaj   +1 more source

Differential effects of sulfhydryl reagents on saxitoxin and tetrodotoxin block of voltage-dependent Na channels [PDF]

, 1994
We have probed a cysteine residue that confers resistance to tetrodotoxin (TTX) block in heart Na channels, with membrane-impermeant, cysteine-specific, methanethiosulfonate (MTS) analogs.
Kirsch, G.E., Hartmann, H.A., Alam, M.
core   +1 more source

Optimization of Sample Preparation for the Identification and Quantification of Saxitoxin in Proficiency Test Mussel Sample using Liquid Chromatography-Tandem Mass Spectrometry

Toxins, 2015
Saxitoxin (STX) and some selected paralytic shellfish poisoning (PSP) analogues in mussel samples were identified and quantified with liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Kirsi Harju, Marja-Leena Rapinoja, Marc-André Avondet, Werner Arnold, Martin Schär, Stephen Burrell, Werner Luginbühl, Paula Vanninen   +7 more
doaj   +1 more source

Results of a Saxitoxin Proficiency Test Including Characterization of Reference Material and Stability Studies

Toxins, 2015
A saxitoxin (STX) proficiency test (PT) was organized as part of the Establishment of Quality Assurance for the Detection of Biological Toxins of Potential Bioterrorism Risk (EQuATox) project.
Kirsi Harju, Marja-Leena Rapinoja, Marc-André Avondet, Werner Arnold, Martin Schär, Werner Luginbühl, Anke Kremp, Sanna Suikkanen, Harri Kankaanpää, Stephen Burrell, Martin Söderström, Paula Vanninen   +11 more
doaj   +1 more source

Dose-Response Modelling of Paralytic Shellfish Poisoning (PSP) in Humans

Toxins, 2018
Paralytic shellfish poisoning (PSP) is caused by a group of marine toxins with saxitoxin (STX) as the reference compound. Symptoms in humans after consumption of contaminated shellfish vary from slight neurological and gastrointestinal effects to fatal ...
Nathalie Arnich, Anne Thébault
doaj   +1 more source

Detection of paralytic shellfish poisoning (PSP) toxins using a colorimetric immunosensing tool for food safety control

Talanta Open
From 1985 to 2018, 35 % of shellfish poisoning cases worldwide were due to paralytic shellfish poisoning (PSP). The main representative toxin congener of the PSP toxin family is saxitoxin (STX), a highly toxic neurotoxin capable of blocking nerve impulse
Ambbar Aballay-González, Sandra Leonardo, Margarita Fernández-Tejedor, Maria Rambla-Alegre, Jorge Diogène, AhlamAl Kharusi, Maximiliano Figueroa, Allisson Astuya-Villalón, Mònica Campàs   +8 more
doaj   +1 more source

Marine Toxins as Pharmaceutical Treasure Troves: A Focus on Saxitoxin Derivatives from a Computational Point of View

Molecules
This work highlights the significant potential of marine toxins, particularly saxitoxin (STX) and its derivatives, in the exploration of novel pharmaceuticals.
Norma Flores-Holguín, Joan S. Salas-Leiva, Erick J. Núñez-Vázquez, Dariel Tovar-Ramírez, Daniel Glossman-Mitnik   +4 more
doaj   +1 more source

Characterization of the Saxitoxin Biosynthetic Starting Gene, sxta in the Toxic Dinoflagellate Alexandrium tamiyavanichii [PDF]

, 2012
Recently, molecular genetics of the Saxitoxin (STX) biosynthesis pathway has become one of the major focuses in paralytic shellfish poisoning (PSP) toxin-related studies after the recent discovery of STX biosynthetic genes in toxic cyanobacteria and ...
Kieng, Soon Hii, Po, Teen Lim, Chui, Pin Leaw, Toh, Hii Tan   +3 more
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