Results 81 to 90 of about 7,557 (161)

Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie

Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.
Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Structural Analysis of Saxitoxin and Neosaxitoxin Toxins with Potential Therapeutic Targets

Biology and Life Sciences Forum
Historically, saxitoxin (STX) and its analogs, like neosaxitoxin (NeoSTX), have been restricted to scientific research due to their potent toxicity, despite their potential as therapeutic agents.
Vanessa dos Santos Silva, Beatriz de Paiva Mendes, Daniel Vinicius Neves de Lima, Tatiana Lúcia Santos Nogueira, Virginia Sara Grancieri do Amaral   +4 more
doaj   +1 more source

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Volume 64, Issue 35, August 25, 2025.
Tetrodotoxin is best known as the poison of the pufferfish, which is a delicacy in Japanese cuisine. Its toxicity arises from the selective blockage of NaV channels, which is depicted for the NaV1.7 pore, highlighting the DEKA motif, which permeates sodium ions.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Copepod Prey Selection and Grazing Efficiency Mediated by Chemical and Morphological Defensive Traits of Cyanobacteria

Toxins, 2020
Phytoplankton anti-grazer traits control zooplankton grazing and are associated with harmful blooms. Yet, how morphological versus chemical phytoplankton defenses regulate zooplankton grazing is poorly understood. We compared zooplankton grazing and prey
Luciana M. Rangel, Lúcia H. S. Silva, Elisabeth J. Faassen, Miquel Lürling, Kemal Ali Ger   +4 more
doaj   +1 more source

Phylogenomic and Pangenomic Assessment of a Mediterranean Strain of Raphidiopsis raciborskii Extends Knowledge of the Global Distribution and Characteristics of a Potentially Toxigenic Cyanobacterium

Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.
The potentially toxigenic cyanobacterium Raphidiopsis raciborskii has spread to temperate regions and produces massive blooms. This study reports the first taxonomic and functional metagenomic assessment of a strain from the Mediterranean, thus filling a significant gap in global distribution.
Nico Salmaso, Leonardo Cerasino, Margherita Di Brizio, Massimo Pindo, Adriano Boscaini   +4 more
wiley   +1 more source

The Acute Toxicity of Tetrodotoxin and Tetrodotoxin–Saxitoxin Mixtures to Mice by Various Routes of Administration

Toxins, 2018
Tetrodotoxin (TTX) is a potent neurotoxin associated with human poisonings through the consumption of pufferfish. More recently, TTX has been identified in bivalve molluscs from diverse geographical environments, including Europe, and is therefore ...
Sarah C. Finch, Michael J. Boundy, D. Tim Harwood   +2 more
doaj   +1 more source

Docking Simulation of the Binding Interactions of Saxitoxin Analogs Produced by the Marine Dinoflagellate Gymnodinium catenatum to the Voltage-Gated Sodium Channel Nav1.4

Toxins, 2016
Saxitoxin (STX) and its analogs are paralytic alkaloid neurotoxins that block the voltage-gated sodium channel pore (Nav), impeding passage of Na+ ions into the intracellular space, and thereby preventing the action potential in the peripheral nervous ...
Lorena M. Durán-Riveroll, Allan D. Cembella, Christine J. Band-Schmidt, José J. Bustillos-Guzmán, José Correa-Basurto   +4 more
doaj   +1 more source

Simultaneous Multiclass Analysis of Cyanotoxins in Cyanobacterial Samples Using Hydrophilic Interaction Liquid Chromatography‐Tandem Mass Spectrometry

Journal of Separation Science, Volume 48, Issue 3, March 2025.
ABSTRACT The proliferation of cyanobacteria can result in algal blooms, which may cause environmental and biological harm due to the production and release of secondary metabolites, or cyanotoxins, into the affected waterway. Cyanobacteria can produce multiple classes of cyanotoxins; therefore, to understand the full toxic load of algal blooms, it is ...
Rosemary Bergin, Siobhan Peters, Simon Mitrovic, David P. Bishop   +3 more
wiley   +1 more source

Tracking a large‐scale and highly toxic Arctic algal bloom: Rapid detection and risk communication

Limnology and Oceanography Letters, Volume 10, Issue 1, Page 62-72, February 2025.
Abstract In recent years, blooms of the neurotoxic dinoflagellate Alexandrium catenella have been documented in Pacific Arctic waters, and the paralytic shellfish toxins (PSTs) that this species produces have been detected throughout the food web. These observations have raised significant concerns about the role that harmful algal blooms (HABs) will ...
Evangeline Fachon, Robert S. Pickart, Gay Sheffield, Emma Pate, Mrunmayee Pathare, Michael L. Brosnahan, Eric Muhlbach, Kali Horn, Nathaniel N. Spada, Anushka Rajagopalan, Peigen Lin, Leah T. McRaven, Loreley S. Lago, Jie Huang, Frank Bahr, Dean A. Stockwell, Katherine A. Hubbard, Thomas J. Farrugia, Kathi A. Lefebvre, Donald M. Anderson   +19 more
wiley   +1 more source

Sub-chronic feeding study of saxitoxin using mice

, 2021
Regulatory limits for shellfish toxins are often set using the results of acute toxicity testing (one-off dose) whereas in reality, people who eat shellfish often do so regularly. It is therefore important to determine the effect of shellfish toxins over
Sarah Finch (15395276), Jan Sprosen (15398369), Michael Boundy (11615197), Vanessa Cave (15394124), Tim Harwood (15394340), John Munday (15395699), Nikki Webb (15408770), Jeane Nicolas (15401726), Ric Broadhurst (7785368)   +8 more
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