Results 111 to 120 of about 1,214 (139)

Targeting Na_v Channels for Pain Relief: Structural Insights and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Xie Y, Huang X, Lu F, Huang J.
europepmc   +1 more source

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Temperature influences the content and biosynthesis gene expression of saxitoxins (STXs) in the toxigenic dinoflagellate Alexandrium pacificum

Science of The Total Environment, 2022
Temperature may affect the production of saxitoxin (STX) and its derivatives (STXs); however, this is still controversial. Further, STX-biosynthesis gene regulation and the relation of its toxicity with temperature are not clearly understood. In the present study, we evaluated the effects of different temperatures (12 °C, 16 °C, and 20 °C) on the ...
Hui, Wang, Hansol, Kim, Hyunjun, Park, Jang-Seu, Ki   +3 more
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Central and peripheral cardio-respiratory effects of saxitoxin (STX) in urethane-anesthetized guinea-pigs

Toxicon, 1993
Effects of saxitoxin (STX; 10 micrograms/kg; i.p.) on cardio-respiratory activities were evaluated in urethane-anesthetized guinea-pigs. Concurrent recordings were made of electrocorticogram (ECoG), bulbar respiratory-related unit activities, diaphragmatic electromyogram (DEMG), electrocardiogram (Lead II ECG), blood pressure, heart rate, end-tidal CO2,
F C, Chang, B J, Benton, R A, Lenz, B R, Capacio   +3 more
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Reversal of Saxitoxin-Induced Cardiorespiratory Failure by a Burro-Raised α-STX Antibody and Oxygen Therapy

Toxicology and Applied Pharmacology, 1994
Reversal of saxitoxin (STX; 10 micrograms/kg, ip) induced cardiorespiratory effects by oxygen ventilation and burro-raised alpha-STX antitoxin (60 mg/kg, i.v.) was studied in urethane-anesthetized guinea pigs acutely instrumented for concurrent monitoring of medullary respiratory-related single units, diaphragm EMG, Lead II electrocardiogram, arterial ...
B J, Benton, V R, Rivera, J F, Hewetson, F C, Chang   +3 more
openaire   +2 more sources

Comparative studies of saxitoxin (STX) -induced cytotoxicity in Neuro-2a and RTG-2 cell lines: An explanation with respect to changes in ROS

Chemosphere, 2018
Saxitoxin (STX), a paralytic shellfish toxin (PST) produced from toxic bloom-forming dinoflagellates, was selected to comparatively investigate the induction of cytotoxicity and apoptosis and a possible mechanism based on changes in the antioxidant defence system of two cellular strains: the mouse neuroblastoma cell line Neuro-2a and the rainbow trout ...
Zhongyuan Zhou, Xuexi Tang, Hongmei Chen, You Wang   +3 more
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Mechanism of Action of Tetrodotoxin (TTX) and Saxitoxin (STX)

1971
Marine toxins such as TTX and STX have aroused the interest of physiologists, biochemists, pharmacologists, and biological warfare people, as well as writers of spy and mystery stories. In the hands of the neuroscientist they have been turned into helpful instruments vital for the study of nerve function and excitable membranes.
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4-Aminopyridine antagonizes the lethal effects of saxitoxin (STX) and tetrodotoxin (TTX)

Toxicon, 1996
B.J. Benton, D.L. Spriggs, B.R. Capacio, F.-C.T. Chang   +3 more
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Saxitoxin (STX)

2009
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