Results 41 to 50 of about 7,557 (161)

Macrocycles of Saxitoxin: Insights into the Structure of Zetekitoxin AB. [PDF]

Chembiochem
Synthetic macrocycles of (+)‐saxitoxin, the causative agent of paralytic shellfish poisoning, have been prepared. These are designed to mimic the macrocyclic core of the proposed structure for zetekitoxin AB. Interestingly, these synthetic macrocycles do not form the C12 hydrate as commonly observed in this family of toxins, casting doubt on the ...
Li W, Paladugu SR, Liles JP, Karthikeyan M, Chase K, Raghuraman S, Sigman MS, Looper RE.   +7 more
europepmc   +2 more sources

4-Aminopyridine Reverses Saxitoxin (STX)- and Tetrodotoxin (TTX)-Induced Cardiorespiratory Depression in Chronically Instrumented Guinea Pigs [PDF]

Fundamental and Applied Toxicology, 1997
The extent to which cardiorespiratory infirmity and other sublethal effects of saxitoxin (STX) and tetrodotoxin (TTX) can be reversed by 4-aminopyridine (4-AP) was investigated in guinea pigs chronically instrumented for the concurrent electrophysiological recordings of electrocorticogram (ECoG), diaphragmatic electromyogram (DEMG), Lead II ...
F C, Chang, D L, Spriggs, B J, Benton, S A, Keller, B R, Capacio   +4 more
openaire   +2 more sources

Characterizing RecA-Independent Induction of Shiga toxin2-encoding Phages by EDTA Treatment [PDF]

, 2013
The bacteriophage life cycle has an important role in Shiga toxin (Stx) expression. The induction of Shiga toxin-encoding phages (Stx phages) increases toxin production as a result of replication of the phage genome, and phage lysis of the host cell also
Muniesa Pérez, Ma. Teresa, Imamovic, Lejla   +1 more
core   +3 more sources

An Electrochemical Ti₃C₂T_x Aptasensor for Sensitive and Label-Free Detection of Marine Biological Toxins

Sensors, 2021
Saxitoxin (STX) belongs to the family of marine biological toxins, which are major contaminants in seafood. The reference methods for STX detection are mouse bioassay and chromatographic analysis, which are time-consuming, high costs, and requirement of ...
Najeeb Ullah, Wei Chen, Beenish Noureen, Yulan Tian, Liping Du, Chunsheng Wu, Jie Ma   +6 more
doaj   +1 more source

Facile and Cost-Effective Detection of Saxitoxin Exploiting Aptamer Structural Switching

Food Technology and Biotechnology, 2015
A simple method to detect saxitoxin (STX), one of the main components of the paralytic shellfish poison from red tide, has been developed. By using a next generation dye for double-stranded DNA we were able to differentiate fluorescence from STX-binding ...
Karol Alfaro, Paulina Bustos, Ciara O´Sullivan, Pablo Conejeros   +3 more
doaj   +1 more source

Electrophysiological Evaluation of Pacific Oyster (Crassostrea gigas) Sensitivity to Saxitoxin and Tetrodotoxin

Marine Drugs, 2021
Pacific oysters (Crassostrea gigas) may bio-accumulate high levels of paralytic shellfish toxins (PST) during harmful algal blooms of the genus Alexandrium. These blooms regularly occur in coastal waters, affecting oyster health and marketability.
Floriane Boullot, Caroline Fabioux, Hélène Hégaret, Pierre Boudry, Philippe Soudant, Evelyne Benoit   +5 more
doaj   +1 more source

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy, Darby Alistair C, Alistair C Darby, Allison Heather E, Rooks David J, Rooks, David, Smith, Darren, Paul CM Fogg, Thomson, Nicholas, David J Rooks, Smith Darren L, McCarthy Alan J, McCarthy, Alan, Heather E Allison, Darren L Smith, Allison, Heather, Fogg Paul CM, Nick R Thomson, Fogg, Paul, Darby, Alistair, Thomson Nick R   +20 more
core   +1 more source

Toxicogenomic Effects of Dissolved Saxitoxin on the Early Life Stages of the Longfin Yellowtail (Seriola rivoliana)

Marine Drugs, 2023
Harmful algal blooms (HABs) can produce a variety of noxious effects and, in some cases, the massive mortality of wild and farmed marine organisms. Some HAB species produce toxins that are released into seawater or transferred via food webs (particulate ...
Colleen Guinle, Erick Julián Núñez-Vázquez, Leyberth José Fernández-Herrera, Daniela Alejandra Corona-Rojas, Dariel Tovar-Ramírez   +4 more
doaj   +1 more source

Amplification of genes associated with saxitoxin biosynthesis in Bacteria associated with pyrodinium Bahamense var. Compressum using Primers designed from other Saxitoxin-producing organisms [PDF]

, 2023
Pyrodinium bahamense var. compressum, the primary producer of saxitoxin (STX) in tropical water, poses a palpable threat to public health and safety. Seafood and aquaculture products contaminated with lethal concentrations of the principal neurotoxin ...
Sylvia Yahumin, Grace Joy Wei Lie Chin, Kenneth Francis Rodrigues   +2 more
core   +1 more source

STX-S vaccine elicited a robust long lasting immune response and a potent booster.

, 2023
STX-S vaccine induced robust expression of SARS-CoV-2 Spike antibodies and IgG levels were maintained overtime. STX-S booster injection induced robust expression of SARS-CoV-2 Spike antibodies. PBS was used as a vehicle control in all studies.
Justin B. Nice (16865908), Kristi Elliott (16865923), Minghao Sun (2368234), Mafalda Cacciottolo (16865905), Michael J. LeClaire (7908947), Meredith Young (5108894), Jenna Angeles (16865920), Ryan Twaddle (16865911), Yujia Li (436877), Ciana L. Mora (16865914), Stephanie Y. Adachi (16865917)   +10 more
core   +1 more source