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The ECM: To Scaffold, or Not to Scaffold, That Is the Question [PDF]
International Journal of Molecular Sciences, 2021 The extracellular matrix (ECM) has pleiotropic effects, ranging from cell adhesion to cell survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the field into two distinct areas—scaffold-based and scaffold-free.
J. Valdoz +7 more
semanticscholar +4 more sources
Scaffold-based molecular design using graph generative model [PDF]
Chem. Sci. 11 (2020) 1153-1164, 2019 Searching new molecules in areas like drug discovery often starts from the core structures of candidate molecules to optimize the properties of interest. The way as such has called for a strategy of designing molecules retaining a particular scaffold as a substructure.
Jaechang Lim +4 more
arxiv +2 more sources
A novel three-dimensional printing of electroconductive scaffolds for bone cancer therapy application [PDF]
Nanomedicine Journal, 2020 Objective(s): Tissue engineering aims to achieve a tissue, which has highly interconnected porous microstructure concurrent with appropriate mechanical and biological properties. Materials and Methods: Therefore, the microstructure scaffolds are of great
Marjan Monshi +5 more
doaj +1 more source
The Effect of Tortuosity on Permeability of Porous Scaffold
Biomedicines, 2023 In designing porous scaffolds, permeability is essential to consider as a function of cell migration and bone tissue regeneration. Good permeability has been achieved by mimicking the complexity of natural cancellous bone.
A. T. Prakoso +8 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 In this work, bioactive glass (BG) particles synthesized by a sol-gel method, hyaluronic acid (HYA) and collagen (COL) extracted from chicken eggshell membrane (ESM), and as-purchased polycaprolactone (PCL) were used to obtain a novel bioactive scaffold ...
N. N. Zurita-Méndez +3 more
doaj +1 more source
Scaffold Fabrication Technologies and Structure/Function Properties in Bone Tissue Engineering
Advanced Functional Materials, 2021 Bone tissue engineering (BTE) is a rapidly growing field aiming to create a biofunctional tissue that can integrate and degrade in vivo to treat diseased or damaged tissue.
M. Collins +5 more
semanticscholar +1 more source
ERK Signals: Scaffolding Scaffolds? [PDF]
Frontiers in Cell and Developmental Biology, 2016 ERK1/2 MAP Kinases become activated in response to multiple intra- and extra-cellular stimuli through a signaling module composed of sequential tiers of cytoplasmic kinases. Scaffold proteins regulate ERK signals by connecting the different components of the module into a multi-enzymatic complex by which signal amplitude and duration are fine-tuned ...
Casar, Berta, Crespo, Piero
openaire +5 more sources
Architecture of the linker-scaffold in the nuclear pore
Science, 2022 Description INTRODUCTION In eukaryotic cells, the selective bidirectional transport of macromolecules between the nucleus and cytoplasm occurs through the nuclear pore complex (NPC).
S. Petrovic +12 more
semanticscholar +1 more source
Scaffolder - software for manual genome scaffolding [PDF]
Source Code for Biology and Medicine, 2012 The assembly of next-generation short-read sequencing data can result in a fragmented non-contiguous set of genomic sequences. Therefore a common step in a genome project is to join neighbouring sequence regions together and fill gaps. This scaffolding step is non-trivial and requires manually editing large blocks of nucleotide sequence.
Michael D. Barton, Hazel A. Barton
openaire +3 more sources
Recent progresses in novel in vitro models of primary neurons: A biomaterial perspective
Frontiers in Bioengineering and Biotechnology, 2022 Central nervous system (CNS) diseases have been a growing threat to the health of humanity, emphasizing the urgent need of exploring the pathogenesis and therapeutic approaches of various CNS diseases.
Jiangang Zhang +5 more
doaj +1 more source