Results 221 to 230 of about 346,909 (265)
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Journal of Knee Surgery, 2014
There are two scaffold products designed for meniscal reconstruction or substitution of partial meniscal defects that are currently available in the Europe: the collagen meniscal implant (CMI; Ivy Sports Medicine, Gräfelfing, Germany) and the polymer scaffold (PS; Actifit, Orteq Bioengineering, London, United Kingdom). The CMI has demonstrated improved
Kevin R, Myers +2 more
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There are two scaffold products designed for meniscal reconstruction or substitution of partial meniscal defects that are currently available in the Europe: the collagen meniscal implant (CMI; Ivy Sports Medicine, Gräfelfing, Germany) and the polymer scaffold (PS; Actifit, Orteq Bioengineering, London, United Kingdom). The CMI has demonstrated improved
Kevin R, Myers +2 more
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Intuitive Ordering of Scaffolds and Scaffold Similarity Searching Using Scaffold Keys
Journal of Chemical Information and Modeling, 2014Scaffold Keys-scaffold descriptors based on simple topological parameters such as number of ring and chain atoms, number and type of heteroatoms, and other simple structural features-are presented. Scaffold Keys enable intuitive ordering of scaffolds from small and simple to large and complex, ordering that is consistent with the way medicinal chemists
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Drug Discovery Today: Technologies, 2004
The aim of scaffold hopping is to discover structurally novel compounds starting from known active compounds by modifying the central core structure of the molecule. Scaffold hopping is a central task of modern medicinal chemistry requiring a multitude of techniques, which are discussed in this article.
Hans-Joachim, Böhm +2 more
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The aim of scaffold hopping is to discover structurally novel compounds starting from known active compounds by modifying the central core structure of the molecule. Scaffold hopping is a central task of modern medicinal chemistry requiring a multitude of techniques, which are discussed in this article.
Hans-Joachim, Böhm +2 more
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Journal of Learning Disabilities, 1998
To situate the concept of scaffolding within a broader context than that addressed by Stone, I discuss it with respect to (a) the historical context of learning disabilities, (b) the emerging focus on learners activity, (c) the reification of learning disabilities, and (d) the unintended effects that frequently occur as a by-product of injudicious (and
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To situate the concept of scaffolding within a broader context than that addressed by Stone, I discuss it with respect to (a) the historical context of learning disabilities, (b) the emerging focus on learners activity, (c) the reification of learning disabilities, and (d) the unintended effects that frequently occur as a by-product of injudicious (and
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The Restriction Scaffold Problem
Journal of Computational Biology, 2002Most shotgun sequencing projects undergo a long and costly phase of finishing, in which a partial assembly forms several contigs whose order, orientation, and relative distance is unknown. We propose here a new technique that supplements the shotgun assembly data by experimentally simple and commonly used complete restriction digests of the target.
Amir Ben-Dor +3 more
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Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2000
The concept of scaffolds that can be equipped with artificial biochemically active sites has gained recent interest in the field of protein design. Members of the lipocalin protein family represent promising model systems in this respect. Especially prototypic lipocalins, such as the retinol-binding protein or the bilin-binding protein (BBP), exhibit a
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The concept of scaffolds that can be equipped with artificial biochemically active sites has gained recent interest in the field of protein design. Members of the lipocalin protein family represent promising model systems in this respect. Especially prototypic lipocalins, such as the retinol-binding protein or the bilin-binding protein (BBP), exhibit a
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Theory in Biosciences, 2016
Descriptions and interpretations of the natural world are dominated by dichotomies such as organism vs. environment, nature vs. nurture, genetic vs. epigenetic, but in the last couple of decades strong dissatisfaction with those partitions has been repeatedly voiced and a number of alternative perspectives have been suggested, from perspectives such as
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Descriptions and interpretations of the natural world are dominated by dichotomies such as organism vs. environment, nature vs. nurture, genetic vs. epigenetic, but in the last couple of decades strong dissatisfaction with those partitions has been repeatedly voiced and a number of alternative perspectives have been suggested, from perspectives such as
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The Scaffold Tree: An Efficient Navigation in the Scaffold Universe
2010The Scaffold Tree algorithm (J Chem Inf Model 47:47-58, 2007) allows to organize large molecular data sets by arranging sets of molecules into a unique tree hierarchy based on their scaffolds, with scaffolds forming leaf nodes of such tree. The hierarchy is created by iterative removal of rings from more complex scaffolds using chemically meaningful ...
Peter, Ertl +2 more
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Journal of Cell Science, 2001
An emerging theme of mitogen-activated protein kinase (MAPK) cascades is that they form molecular assemblies within cells; the spatial organization of which is provided by scaffold proteins. Yeast Ste5p was the first MAPK cascade scaffold to be described.
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An emerging theme of mitogen-activated protein kinase (MAPK) cascades is that they form molecular assemblies within cells; the spatial organization of which is provided by scaffold proteins. Yeast Ste5p was the first MAPK cascade scaffold to be described.
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SCAFFOLDING POST FOR A BUILDING SCAFFOLD
2017Die Erfindung betrifft einen Gerüststiel für ein Baugerüst Gerüststiele für Baugerüste sind im Stand der Technik grundsätzlich hinlänglich bekannt. Sie bestehen typischerweise aus einem Rohr (110) und einem mit dem Rohr verschweißten Rohrverbinder (120) zum Aufstecken eines weiteren Rohres, wenn das Gerüst in die Höhe gebaut werden soll.
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