Results 91 to 100 of about 192,579 (307)
Weak scalar curvature lower bounds along Ricci flow [PDF]
, 2023 Wenshuai Jiang +2 more
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Rigity results on $\rho$-Einstein solitons with zero scalar curvature. [PDF]
, 2021 Romildo Pina +2 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
On complete hypersurfaces with constant scalar curvature $n(n-1)$ in the unit sphere [PDF]
, 2022 Jinchuan Bai, Yong Luo
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Hypersurfaces with constant scalar curvature and constant mean curvature
Annals of Global Analysis and Geometry, 1995 According to the authors' abstract, ``non-spherical hypersurfaces in \(E^ 4\) with non-zero constant mean curvature and constant scalar curvature are the only hypersurfaces possessing the following property: Its position vector can be written as a sum of two non-constant maps, which are eigenmaps of the Laplacian operator with corresponding eigenvalues
Hasanis, T., Vlachos, T.
openaire +2 more sources
D'Atri spaces and the total scalar curvature of hemispheres, tubes and cylinders. [PDF]
Rev Mat Complut, 2023 Csikós B, Elnashar A, Horváth M.
europepmc +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Non-minimal two-loop inflation
Physics Letters B, 2015 We investigate the chaotic inflationary model using the two-loop effective potential of a self-interacting scalar field theory in curved spacetime. We use the potential which contains a non-minimal scalar curvature coupling and a quartic scalar self ...
Tomohiro Inagaki +2 more
doaj +1 more source