Results 111 to 120 of about 192,579 (307)

Thermodynamic geometry of holographic superconductors

open access: yesPhysics Letters B, 2016
We obtain the thermodynamic geometry of a (2+1) dimensional strongly coupled quantum field theory at a finite temperature in a holographic setup, through the gauge/gravity correspondence.
Sayan Basak   +3 more
doaj   +1 more source

Scalar curvature of definable CAT-spaces [PDF]

open access: yesadvg, 2003
For a compact connected set belonging to some \(o\)-minimal structure (e.g. a semialgebraic or subanalytic set) the author defined the notion of scalar curvature measure which shares many of the properties of the standard scalar curvature of Riemannian manifolds. Carrying on previous work [\textit{A. Bernig}, Adv. Geom. 2, 29-55 (2002; Zbl 1027.53041)]
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

On the (α, β)-Metrics of Conformally Flat Type With Weakly Isotropic Scalar Curvature

open access: yesJournal of Mathematics
This paper considers Matsumoto metrics of conformally flat type that have weakly isotropic scalar curvature and proves that they reduce to Riemannian metrics or locally Minkowski metrics. In this case, they have zero scalar curvature. Similar results are
Mosayeb Zohrehvand
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

On the role of the parity violating Hojman–Holst term in gravity theories

open access: yesPhysics Letters B
We study Parity Violating Gravity Theories whose gravitational Lagrangian is a generic function of the scalar curvature and the parity odd curvature pseudoscalar, commonly known as the Holst (or Hojmann) term.
Damianos Iosifidis
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

S- and T-self-dualities in dilatonic $$f(R)$$ f ( R ) theories

open access: yesEuropean Physical Journal C: Particles and Fields, 2017
We search for theories, in general spacetime dimensions, that would incorporate a dilaton and higher powers of the scalar Ricci curvature such that they have exact S- or T-self-dualities. The theories we find are free of Ostrogradsky instabilities.
Tonguç Rador
doaj   +1 more source

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