Results 111 to 120 of about 693,970 (340)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Asymptotic generalized extended uncertainty principle
European Physical Journal C: Particles and Fields, 2020 We present a formalism which allows for the perturbative derivation of the Extended Uncertainty Principle (EUP) for arbitrary spatial curvature models and observers.
Mariusz P. Da̧browski, Fabian Wagner
doaj +1 more source
On Square metrics of scalar flag curvature [PDF]
Israel Journal of Mathematics, 2018 We consider a special class of Finsler metrics --- square metrics which are defined by a Riemannian metric and a 1-form on a manifold. We show that an analogue of the Beltrami Theorem in Riemannian geometry is still true for square metrics in dimension $n\ge 3$, namely, an $n(\ge 3)$-dimensional square metric is locally projectively flat if and only if
Shen, Zhongmin, Yang, Guojun
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Deformation of the scalar curvature and the mean curvature
, 2020 On a compact manifold $M$ with boundary $\partial M$, we study the problem of prescribing the scalar curvature in $M$ and the mean curvature on the boundary $\partial M$ simultaneously. To do this, we introduce the notion of singular metric, which is inspired by the early work of Fischer-Marsden in [18] and Lin-Yuan in [23] for closed manifold. We show
Ho, Pak Tung, Huang, Yen-Chang
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Kropina Metrics with Isotropic Scalar Curvature via Navigation Data
MathematicsThrough an interesting physical perspective and a certain contraction of the Ricci curvature tensor in Finsler geometry, Akbar-Zadeh introduced the concept of scalar curvature for the Finsler metric.
Yongling Ma +2 more
doaj +1 more source
O(p + 1) x O(p + 1)-Invariant hypersurfaces with zero scalar curvature in euclidean space
Anais da Academia Brasileira de Ciências, 2000 We use equivariant geometry methods to study and classify zero scalar curvature O(p + 1) x O(p + 1)-invariant hypersurfaces in R2p+2 with p > 1.
JOCELINO SATO
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Entire Scalar Curvature Flow and Hypersurfaces of Constant Scalar Curvature in Minkowski Space [PDF]
Methods and Applications of Analysis, 2009 We prove existence in the Minkowski space of entire spacelike hypersurfaces with constant negative scalar curvature and given set of lightlike directions at infinity; we also construct the entire scalar curvature flow with prescribed set of lightlike directions at infinity, and prove that the flow converges to a spacelike hypersurface with constant ...
openaire +3 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source