Results 121 to 130 of about 693,970 (340)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exact black hole solutions with a conformally coupled scalar field and dynamic Ricci curvature in [PDF]
, 2021 Thanasis Karakasis +3 more
openalex +3 more sources
Kinetic scalar curvature extended f(R) gravity
Nuclear Physics B, 2018 In this work we study a modified version of vacuum f(R) gravity with a kinetic term which consists of the first derivatives of the Ricci scalar. We develop the general formalism of this kinetic Ricci modified f(R) gravity and we emphasize on cosmological
S.V. Chervon +4 more
doaj +1 more source
D'Atri spaces and the total scalar curvature of hemispheres, tubes and cylinders. [PDF]
Rev Mat Complut, 2023 Csikós B, Elnashar A, Horváth M.
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Non-minimal two-loop inflation
Physics Letters B, 2015 We investigate the chaotic inflationary model using the two-loop effective potential of a self-interacting scalar field theory in curved spacetime. We use the potential which contains a non-minimal scalar curvature coupling and a quartic scalar self ...
Tomohiro Inagaki +2 more
doaj +1 more source
ECG Classification Based on Wasserstein Scalar Curvature. [PDF]
Entropy (Basel), 2022 Sun F, Ni Y, Luo Y, Sun H.
europepmc +1 more source