Results 121 to 130 of about 681,612 (344)
Kropina Metrics with Isotropic Scalar Curvature via Navigation Data
MathematicsThrough an interesting physical perspective and a certain contraction of the Ricci curvature tensor in Finsler geometry, Akbar-Zadeh introduced the concept of scalar curvature for the Finsler metric.
Yongling Ma +2 more
doaj +1 more source
On isotropic Berwald scalar curvature
International Journal of Mathematics, 2023 In this paper, we establish a closer relation between the Berwald scalar curvature and the [Formula: see text]-curvature. In fact, we prove that a Finsler metric has isotropic Berwald scalar curvature if and only if it has weakly isotropic [Formula: see text]-curvature. For Finsler metrics of scalar flag curvature and of weakly isotropic [Formula: see
openaire +2 more sources
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Non-minimal two-loop inflation
Physics Letters B, 2015 We investigate the chaotic inflationary model using the two-loop effective potential of a self-interacting scalar field theory in curved spacetime. We use the potential which contains a non-minimal scalar curvature coupling and a quartic scalar self ...
Tomohiro Inagaki +2 more
doaj +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Kinetic scalar curvature extended f(R) gravity
Nuclear Physics B, 2018 In this work we study a modified version of vacuum f(R) gravity with a kinetic term which consists of the first derivatives of the Ricci scalar. We develop the general formalism of this kinetic Ricci modified f(R) gravity and we emphasize on cosmological
S.V. Chervon +4 more
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Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
D'Atri spaces and the total scalar curvature of hemispheres, tubes and cylinders. [PDF]
Rev Mat Complut, 2023 Csikós B, Elnashar A, Horváth M.
europepmc +1 more source