Results 151 to 160 of about 681,612 (344)

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

open access: yesMolecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova   +26 more
wiley   +1 more source

Effective Gravitational “Constant” in Scalar-(Curvature)Tensor and Scalar-Torsion Gravities

open access: yesUniverse, 2017
In theories where a scalar field couples nonminimally to gravity, the effective gravitational “constant” becomes dependent on the value of the scalar field.
Laur Järv
doaj   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

Colliding scalar pulses in the Einstein-Gauss-Bonnet gravity

open access: yesEPJ Web of Conferences, 2018
We numerically investigated how the nonlinear dynamics depends on the dimensionality and on the higher-order curvature corrections in the form of Gauss-Bonnet (GB) terms, with a model of colliding scalar pulses in plane-symmetric space-time.
Shinkai Hisaaki, Torii Takashi
doaj   +1 more source

Deformation of the scalar curvature and the mean curvature

open access: yes, 2020
On a compact manifold $M$ with boundary $\partial M$, we study the problem of prescribing the scalar curvature in $M$ and the mean curvature on the boundary $\partial M$ simultaneously. To do this, we introduce the notion of singular metric, which is inspired by the early work of Fischer-Marsden in [18] and Lin-Yuan in [23] for closed manifold. We show
Ho, Pak Tung, Huang, Yen-Chang
openaire   +2 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Hagedorn temperature from the thermal scalar in AdS and pp-wave backgrounds

open access: yesJournal of High Energy Physics
We propose a thermal scalar equation of motion (EOM) that takes into account curvature corrections for backgrounds supported by Ramond-Ramond fluxes.
Troels Harmark
doaj   +1 more source

Multiply Warped Products with a Semisymmetric Metric Connection

open access: yesAbstract and Applied Analysis, 2014
We study the Einstein multiply warped products with a semisymmetric metric connection and the multiply warped products with a semisymmetric metric connection with constant scalar curvature, and we apply our results to generalized Robertson-Walker space ...
Yong Wang
doaj   +1 more source

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