Results 71 to 80 of about 693,970 (340)

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

CCT4 promotes tunneling nanotube formation

open access: yesFEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto   +3 more
wiley   +1 more source

A Dozen Problems, Questions and Conjectures About Positive Scalar Curvature [PDF]

open access: yes, 2017
Unlike manifolds with positive sectional and with positive Ricci curvatures which aggregate to modest (roughly) convex islands in the vastness of all Riemannian spaces, the domain \(\{\mathcal{SC}>0\}\) of manifolds with positive scalar curvatures ...
M. Gromov
semanticscholar   +1 more source

Volume comparison with respect to scalar curvature [PDF]

open access: yesAnalysis & PDE, 2016
In this article, we investigate the volume comparison with respect to scalar curvature. In particular, we show volume comparison hold for small geodesic balls of metrics near $V$-static metrics.
Wei Yuan
semanticscholar   +1 more source

Critical metrics of the $L^2$-norm of the scalar curvature

open access: yes, 2013
In this paper we investigate complete critical metrics of the $L^{2}$-norm of the scalar curvature. We prove that any complete critical metric with positive scalar curvature has constant scalar curvature and we characterize critical metrics with ...
Catino, Giovanni
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Remarks on a result of Chen-Cheng

open access: yesComplex Manifolds
In their seminal work, Chen and Cheng proved a priori estimates for the constant scalar curvature metrics on compact Kähler manifolds. They also prove C3,α{C}^{3,\alpha }-estimate for the potential of the Kähler metrics under boundedness assumption on ...
Lu Zhiqin, Seyyedali Reza
doaj   +1 more source

Disformal transformation of cosmological perturbations

open access: yesPhysics Letters B, 2014
We investigate the gauge-invariant cosmological perturbations in the gravity and matter frames in the general scalar–tensor theory where two frames are related by the disformal transformation.
Masato Minamitsuji
doaj   +1 more source

Isoperimetry, Scalar Curvature, and Mass in Asymptotically Flat Riemannian 3‐Manifolds [PDF]

open access: yesCommunications on Pure and Applied Mathematics, 2016
Let (M, g) be an asymptotically flat Riemannian 3‐manifold with nonnegative scalar curvature and positive mass. We show that each leaf of the canonical foliation of the end of (M, g) through stable constant mean curvature spheres encloses more volume ...
Otis Chodosh   +3 more
semanticscholar   +1 more source

Scalar curvatures on 𝑆² [PDF]

open access: yesTransactions of the American Mathematical Society, 1987
A theorem for the existence of solutions of the nonlinear elliptic equation − Δ u + 2 = R ( x ) e u , x ∈ S 2 - \Delta u + 2 = R(x){e^u},\;x \in ...
Wen Xiong Chen, Wei Yue Ding
openaire   +1 more source

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