Results 81 to 90 of about 192,579 (307)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

O(p + 1) x O(p + 1)-Invariant hypersurfaces with zero scalar curvature in euclidean space

Anais da Academia Brasileira de Ciências, 2000
We use equivariant geometry methods to study and classify zero scalar curvature O(p + 1) x O(p + 1)-invariant hypersurfaces in R2p+2 with p > 1.
JOCELINO SATO
doaj   +1 more source

Asymptotic generalized extended uncertainty principle

European Physical Journal C: Particles and Fields, 2020
We present a formalism which allows for the perturbative derivation of the Extended Uncertainty Principle (EUP) for arbitrary spatial curvature models and observers.
Mariusz P. Da̧browski, Fabian Wagner
doaj   +1 more source

RANDERS METRICS OF SCALAR FLAG CURVATURE [PDF]

Journal of the Australian Mathematical Society, 2009
AbstractWe study an important class of Finsler metrics, namely, Randers metrics. We classify Randers metrics of scalar flag curvature whose S-curvatures are isotropic. This class of Randers metrics contains all projectively flat Randers metrics with isotropic S-curvature and Randers metrics of constant flag curvature.
Cheng, Xinyue, Shen, Zhongmin
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Epsilon regularity under scalar curvature and entropy lower bounds and volume upper bounds [PDF]

, 2022
Robin Neumayer
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Kropina Metrics with Isotropic Scalar Curvature via Navigation Data

Mathematics
Through an interesting physical perspective and a certain contraction of the Ricci curvature tensor in Finsler geometry, Akbar-Zadeh introduced the concept of scalar curvature for the Finsler metric.
Yongling Ma, Xiaoling Zhang, Mengyuan Zhang   +2 more
doaj   +1 more source

Scalar Curvature of a Causal Set [PDF]

Physical Review Letters, 2010
A one parameter family of retarded linear operators on scalar fields on causal sets is introduced. When the causal set is well approximated by 4 dimensional Minkowski spacetime, the operators are Lorentz invariant but nonlocal, are parametrized by the scale of the nonlocality, and approximate the continuum scalar D'Alembertian square when acting on ...
Benincasa, Dionigi Maria Teofilo, Dowker F.   +1 more
openaire   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source