Space station full-scale docking/berthing mechanisms development [PDF]
One of the most critical operational functions for the space station is the orbital docking between the station and the STS orbiter. The program to design, fabricate, and test docking/berthing mechanisms for the space station is described.
Buchanan, David B. +2 more
core +1 more source
Sustainable management of water bodies for small-scale fisheries resorces research and development [PDF]
, 1999 The rapid growth of both formal and informal high density urban settlements around major water resources has led to increased pollution of streams, rivers, lakes and estuaries, due to contaminated runoff from these developments.
Ajao, E.A.
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Development and Validation of the Single Item Narcissism Scale (SINS)
, 2014 Main Objectives: The narcissistic personality is characterized by grandiosity, entitlement, and low empathy. This paper describes the development and validation of the Single Item Narcissism Scale (SINS).
Bushman, Brad J. +2 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Prediction of TBM penetration rate for different surrounding rocks and cutter head diameters
HeliyonThe penetration rate (PR) of tunnel boring machines (TBMs) is often used to evaluate tunneling performance and predict construction period costs. However, most penetration rate (PR) prediction models are based on a single specific project, which leads to
Yang Yalei +4 more
doaj +1 more source
Development of a Real-Time Controlled Bio-Liquor Circulation System for Swine Farms: A Lab-Scale Study [PDF]
, 2021 Seung‐Soo Kim +4 more
openalex +1 more source
Changes in teaching and learning: what counts, who to, and how is it counted? [PDF]
, 2015 This paper builds on and contributes to the evidence that links teacher development programmes and educational technology programmes in low-to-middle income countries, to improvements in quality.
Mathew, Rama +2 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
CSM Testbed Development and Large-Scale Structural Applications [PDF]
A research activity called Computational Structural Mechanics (CSM) conducted at the NASA Langley Research Center is described. This activity is developing advanced structural analysis and computational methods that exploit high-performance computers ...
Gillian, R. E. +6 more
core +1 more source