Results 81 to 90 of about 3,504,743 (313)

Early Childhood Development: Wealth, the Nurturing Environment and Inequality First Results from the PRIDI Database [PDF]

, 2016
This paper presents findings from the Regional Project on Child Development Indicators, PRIDI for its acronym in Spanish. PRIDI created a new tool, the Engle Scale, for evaluating development in children aged 24 to 59 months in four domains: cognition ...
Inter-American Development Bank
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Harm Perception and Result Awareness Study for Tertiary Prevention in Patients with Comorbidity of Substance Use Disorder and Bipolar Disorder

Psychiatry International
The long-term protective effect of self-awareness in substance use disorders, described as a type of brain disease, is currently being discussed and is called tertiary prevention.
Nevzat Tarhan, Çiğdem Demirsoy, Aylin Tutgun-Ünal   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Country Program Evaluation: Panama (2005-2009) [PDF]

, 2009
This Country Program Evaluation (RE-359) covers the period from 2005 to 2009. OVE\u27s most significant recommendation stemming from the analysis is that, if this is one of the new administration\u27s priorities, the next strategy should design an ...
Inter-American Development Bank
core   +1 more source

Development of a Regimen Comprehension Scale.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1997
Whether elderly patients can take prescription drugs as directed by a physician is often unclear. So elderly patients could receive adequate instruction regarding their medications, we developed a regimen comprehension scale (RCS) with simple questions regarding information on dosage and administration.
Shiomi, Toshiaki, Okada, Hiroshi, Sanada, Susumu, Kurono, Syunsuke, Kobayashi, Tadashi   +4 more
openaire   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Intelligent identification and warning method of disc cutter abnormal wear in TBM construction based on extreme learning machine

Scientific Reports
Abnormal cutter wear has a serious impact on TBM construction. If not found in time, it may lead to the cutterhead overall failure. Aiming at this problem, a general model and method to identify and warn the abnormal cutter wear using Extreme Learning ...
Qingwei Li, Lijie Du, Yalei Yang, Zhihua Ni, Xiangbo Zhao   +4 more
doaj   +1 more source