Results 51 to 60 of about 1,088,259 (218)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The Impact of Nonrenewable Resource Abundance on Factor Shares

برنامه‌ریزی و بودجه, 2019
The share of factors of production in the GDP of a country represents an overall picture of its aggregate production technology. The share of reproducible factors (i.e., physical capital and human capital), and the share of non-reproducible factors (i.e.,
Ali Motavasseli, Najmeh Khani-Saryazdi
doaj  

Data Envelopment Analysis (DEA) to Estimate Technical and Scale Efficiencies of Smallholder Pineapple Farmers in Ghana

Agriculture
This study focuses on evaluating the technical and scale efficiencies of smallholder pineapple farmers in Ghana’s Central Region. We surveyed 320 participants selected using random sampling and applied an input-oriented Data Envelopment Analysis (DEA ...
Kwaku Boakye, Yu-Feng Lee, Festus F. Annor, Samuel K. N. Dadzie, Iddrisu Salifu   +4 more
doaj   +1 more source

Efficiency of Small Landholders in Eastern Paraguay

Journal of Agricultural and Resource Economics, 2002
The relative efficiency levels of 283 rural households from three regions in eastern Paraguay are measured using a nonparametric approach. Technical, allocative, and scale efficiency measures are calculated both at national and regional levels, and ...
Diana K. Fletschner, Lydia Zepeda
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A Data Envelopment Analysis of Inland Ports’ Efficiency: Evidence from the Romanian Danube Ports

Systems
Background: Ports play a strategic role in the efficiency and sustainability of European transport corridors; however, empirical evidence on their performance remains limited, particularly for Eastern European countries.
Eugen Rosca, Ilona Costea, Anamaria Ilie, Marjana Petrović, Florin Rusca   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Efisiensi Teknis Produksi Tandan Buah Segar (TBS) Kelapa Sawit: Studi pada Afdeling I dan II Kebun S PTPN IV Regional V, Kalimantan Barat

Jurnal Agro Industri Perkebunan
Oil palm production efficiency plays a crucial role in maintaining productivity and sustainability amid fluctuating yields and increasing input use. This study aims to measure the technical efficiency of palm oil production at PT Perkebunan Nusantara IV ...
Nikolas Ardiano, Erlinda Yurisinthae, Wanti Fitrianti   +2 more
doaj   +1 more source