Results 41 to 50 of about 939,708 (316)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Anomaly Detection Based on Markovian Geometric Diffusion
Machine Learning and Knowledge ExtractionAutomatic anomaly detection is vital in domains such as healthcare, finance, and cybersecurity, where subtle deviations may signal fraud, failures, or impending risks.
Erikson Carlos Ramos +2 more
doaj +1 more source
Technical Note: The horizontal scale dependence of the cloud overlap parameter α [PDF]
Atmospheric Chemistry and Physics, 2014 The cloud overlap parameter α relates the combined cloud fraction between two altitude levels in a grid box to the cloud fraction as derived under the maximum and random overlap assumptions. In a number of published studies in this and other journals, it
I. Astin, L. Di Girolamo
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
How to select the most relevant 3D roughness parameters of a surface [PDF]
, 2014 In order to conduct a comprehensive roughness analysis, around sixty 3D roughness parameters are created to describe most of the surface morphology with regard to specific functions, properties or applications.
Bigerelle, M. +11 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On Shrinkage Estimation for the Scale Parameter of Weibull Distribution
Data Science Journal, 2009 In the present article, some shrinkage testimators for the scale parameter of a two-parameter Weibull life testing model have been suggested under the LINEX loss function assuming the shape parameter is to be known.
Gyan Prakash, D C Singh, S K Sinha
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Uniqueness, scale, and resolution issues in groundwater model parameter identification
Water Science and Engineering, 2015 This paper first visits uniqueness, scale, and resolution issues in groundwater flow forward modeling problems. It then makes the point that non-unique solutions to groundwater flow inverse problems arise from a lack of information necessary to make the ...
Tian-chyi J. Yeh +6 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source