Results 141 to 150 of about 9,624,872 (292)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Notion of uncertainty space scale and its application

Sistemnì Doslìdženâ ta Informacìjnì Tehnologìï, 2019
A new notion of uncertainty space scale is introduced which makes it possible: 1) to find something in common among all the well-known kinds of averages (in particular to separate the subclass of averaging uncertainty spaces); 2) to construct even ...
N. N. Diduk
doaj  

Complexity as a Sclae-Space for the Medial Axis Transform [PDF]

, 1993
The medial axis skeleton is a thin line graph that preserves the topology of a region. The skeleton has often been cited as a useful representation for shape description, region interpretation, and object recognition.
Chaney, Ronald
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Path integration in large-scale space and with novel geometries: Comparing vector addition and encoding-error models. [PDF]

PLoS Comput Biol, 2020
Harootonian SK, Wilson RC, Hejtmánek L, Ziskin EM, Ekstrom AD.   +4 more
europepmc   +1 more source

Toledo Scale Demo

, 2010
Toledo Scales Demonstration at Edgewater Grocery Co.
Toledo Computing Scale Co.
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Piantanida Near Space Balloon Gondola Engineered Drawing and Details

Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core   +3 more sources

Mustache: multi-scale detection of chromatin loops from Hi-C and Micro-C maps using scale-space representation. [PDF]

Genome Biol, 2020
Roayaei Ardakany A, Gezer HT, Lonardi S, Ay F.   +3 more
europepmc   +1 more source