Results 101 to 110 of about 1,321,726 (316)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

'Validation' in genome-scale research [PDF]

open access: yesJournal of Biology, 2008
The individual 'validation' experiments typically included in papers reporting genome-scale studies often do not reflect the overall merits of the work.
openaire   +2 more sources

Validation of an HIV-related stigma scale among health care providers in a resource-poor Ethiopian setting [PDF]

open access: yes, 2012
Garumma Tolu Feyissa1, Lakew Abebe1, Eshetu Girma1, Mirkuzie Woldie21Department of Health Education and Behavioral Sciences, 2Department of Health Services Management, Jimma University, Jimma, EthiopiaBackground: Stigma and discrimination (SAD) against ...
Woldie, M.   +7 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Validation of the Social Inclusion Scale with Students

open access: yesSocial Inclusion, 2015
Interventions (such as participatory arts projects) aimed at increasing social inclusion are increasingly in operation, as social inclusion is proving to play a key role in recovery from mental ill health and the promotion of mental wellbeing.
Ceri Wilson, Jenny Secker
doaj   +1 more source

Hierarchical confirmatory factor analysis of the flow state scale in exercise [PDF]

open access: yes, 2000
In this study, we examined the factor structure and internal consistency of the Flow State Scale using responses of exercise participants.This self-report questionnaire consists of nine subscales designed to assess flow in sport and physical activity. It
Terry, PC   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Yönetim Araştırmalarında Ölçek Kullanımı [PDF]

open access: yesYönetim ve Organizasyon Araştırmaları Dergisi, 2018
Yönetim araştırmalarında ölçek kullanımı ile ilgili genel-geçer bir çerçeve sunmayı amaçlayan bu çalışmada, aynı zamanda Türk yönetim yazınında son on yılda ölçek kullanılan makaleler de incelenerek bir durum değerlendirmesi yapılmıştır. Bu konuda on yıl
Erkan Erdemir
doaj  

Sensitivity to Pain Traumatization Scale: development, validation, and preliminary findings

open access: yes, 2017
Joel Katz,1,2 Samantha R Fashler,1 Claire Wicks,1 M Gabrielle Pagé,3 Kaley M Roosen,1 Valery Kleiman,1 Hance Clarke2 1Department of Psychology, York University, 2Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, ON ...
Kleiman V   +6 more
core  

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