Results 111 to 120 of about 1,321,726 (316)

Development and cross-national validation of the Emotional Effort Scale (EEF) [PDF]

, 2013
Background: Researchers define Emotional Labour (EL) as the effort associated with meeting the emotional requirements of the job, yet nobody has ever directly tested this effort.
Quinones-Garcia, Cristina, Rodríguez Carvajal, Raquel, Rodriguez-Carvajal, Raquel, Clarke, Nicholas, Quiñones García, Cristina, Moreno-Jiménez, Bernardo, Moreno Jiménez, Bernardo   +6 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Creation and validation of the belief in the supernatural scale

, 2018
This study aimed to create and validate a new scale, the “Belief in the Supernatural Scale.” Study one used an Exploratory Factor Analysis (EFA) to reduce an initial item pool of 71 items to 44 and to identify a factor structure with 382 participants.
Schofield, M.B., Baker, I.S., Sheffield, D., Staples, P.   +3 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Validation of the French version of the Body Awareness Questionnaire: toward a way to assess alexisomia

Frontiers in Psychology
BackgroundAwareness of one's own states is a particularly important part of cognition and emotion regulation. Recently, the concept of alexisomia has been used to refer to lack of awareness and expression of somatic sensations.
Arnaud Carre, Rebecca Shankland, Philippe Guillaume, Jeanne Duclos, Claire El-Jor, Sonia Pellissier, Valentin Flaudias, Valentin Flaudias   +7 more
doaj   +1 more source

The Polycystic Ovary Syndrome Quality of Life scale (PCOSQOL): Development and preliminary validation [PDF]

, 2018
Polycystic ovary syndrome is an endocrine disorder amongst women, which can negatively impact quality of life. Research proposes that a more sensitive PCOS quality of life measure is needed.
Sheffield, David, Sophie Williams, Knibb, Rebecca C, Knibb, Rebecca C., Rebecca C Knibb, Williams, Sophie, David Sheffield   +6 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A multidimensional definition of partner abuse: Development and preliminary validation of the Composite Abuse Scale

, 1999
The Composite Abuse Scale's development and initial validation survey is presented in this article. The items of the Composite Abuse Scale were derived from four other scales: Conflict Tactics Scale, Measure of Wife Abuse, Inventory of Spouse Abuse, and ...
Sheehan, Mary C., Hegarty, Kelsey, Schonfeld, Cynthia C., Sheehan, Mary, Schonfeld, Cynthia   +4 more
core   +1 more source