Results 131 to 140 of about 3,081,987 (307)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Psychometric Properties of the Serbian Teen Version of the Problem Areas in Diabetes Scale—A Validation Study

Nursing Reports
Screening for diabetes-specific distress should be considered a standard component of diabetes management. This study aimed to evaluate the psychometric properties of the Serbian adaptation of the Problem Areas in Diabetes—Teen Version (PAID-T). Methods:
Mirjana Smudja, Tatjana Milenković, Ivana Minaković, Vera Zdravković, Sandra Mitić, Ana Miljković, Dragana Milutinović   +6 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Adaptation of e-health impact questionnaire into Turkish: a validity and reliability study

Frontiers in Digital Health
Introductione-Health refers to the use of information and communication technologies (ICT) for health-related services. e-Health aims to distribute scarce resources to areas in need more efficiently and to reduce the cost of health care delivery. However,
Mustafa Kafes, Serife Didem Kaya
doaj   +1 more source

The Social Comparison Scale: Testing the Validity, Reliability, and Applicability of the IOWA-Netherlands Comparison Orientation Measure (INCOM) on the German Population [PDF]

Social comparisons are an essential source of information about the self. Research in social psychology has shown individual variation in the tendency toward comparison with other people's opinions and abilities, raising the question of whether social ...
Jürgen Schupp, Simone Schneider
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Estudio psicométrico del cuestionario de intenciones emprendedoras en jóvenes mexicanos - Psychometric study of the entrepreneurial intentions questionnaire in Mexican youth

Suma de Negocios
Introducción/objetivo: el emprendimiento se ha consolidado como un motor clave para el crecimiento personal y el desarrollo económico en distintos ámbitos.
Ignacio Norambuena , Felipe Quintano , Leonor Riquelme , José Sepúlveda, Cristina Tavera , Selene Pérez , Crisóforo Álvarez, Roque López   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Organizational legitimacy in Latin American higher education: scale development and validation

Cogent Education
The absence of validated measurement instruments for organizational legitimacy in higher education has constrained theoretical advancement and empirical research, particularly in Latin America, where universities face unique legitimacy challenges ...
Leonardo Cañizares-Cedeño, Blanca Estela Hernández Bonilla   +1 more
doaj   +1 more source