Results 121 to 130 of about 7,437,410 (311)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Organizational legitimacy in Latin American higher education: scale development and validation

Cogent Education
The absence of validated measurement instruments for organizational legitimacy in higher education has constrained theoretical advancement and empirical research, particularly in Latin America, where universities face unique legitimacy challenges ...
Leonardo Cañizares-Cedeño, Blanca Estela Hernández Bonilla   +1 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Development and validation of a competence measurement scale for digital experiential learning in child sexual abuse prevention education for student teachers

Frontiers in Education
IntroductionThis study aims to develop and validate a measurement scale for student teachers' competence in designing and implementing digital experiential learning activities on child abuse prevention education.MethodsData were collected from 1,379 ...
Loan Thi Bui, Loan Thi Tran, Ngan Thi Lan Nguyen, Huong Thi Thu Lai   +3 more
doaj   +1 more source

Yönetim Araştırmalarında Ölçek Kullanımı [PDF]

Yönetim ve Organizasyon Araştırmaları Dergisi, 2018
Yönetim araştırmalarında ölçek kullanımı ile ilgili genel-geçer bir çerçeve sunmayı amaçlayan bu çalışmada, aynı zamanda Türk yönetim yazınında son on yılda ölçek kullanılan makaleler de incelenerek bir durum değerlendirmesi yapılmıştır. Bu konuda on yıl
Erkan Erdemir
doaj  

Scale Validation

, 2017
Validation Projects for the VCU Vengeance Scale, Need For Pain Scale, and Aggression Addiction ...
David Chester
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Cross-Sectional Dataset for the Validation of an L2 Student Engagement Scale: Evidence from a Vietnamese Context

Journal of Open Humanities Data
This dataset is for the validation of a second language (L2) student engagement scale in the English as a foreign language (EFL) context of Vietnam.
Le Thi Diem Lan, Duong Minh Tuan
doaj   +1 more source

Toledo Scale Demo

, 2010
Toledo Scales Demonstration at Edgewater Grocery Co.
Toledo Computing Scale Co.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source