Results 131 to 140 of about 11,492,110 (391)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Adaptação da Escala de Silhuetas Brasileiras para uso digital

Jornal Brasileiro de Psiquiatria
RESUMO Objetivo Adaptar a escala de silhuetas originais em cartões de papel e validar para uso digital. Métodos Participaram dessa pesquisa 88 jovens, os quais foram avaliados quanto ao índice de massa corporal (IMC) e questões sobre a imagem ...
Simone Cardoso Freire, Mauro Fisberg
doaj   +1 more source

Validation of the Spanish version of the Lawton IADL Scale for its application in elderly people [PDF]

, 2012
Itziar Vergara, Amaia Bilbao, Miren Orive, Susana García‐Gutiérrez, Gemma Navarro, José M. Quintana   +5 more
openalex   +1 more source

Gleaning insights from German energy transition and large-scale underground energy storage for China’s carbon neutrality

, 2023
Yachen Xie, Xuning Wu, Zhengmeng Hou, Zaoyuan Li, Jiashun Luo, Christian Truitt Lüddeke, Liangchao Huang, Lin Wu, Jianxing Liao   +8 more
openalex   +1 more source

MS-FRCNN: A Multi-Scale Faster RCNN Model for Small Target Forest Fire Detection [PDF]

, 2023
Lin Zhang, Mingyang Wang, Yunhong Ding, Xiangfeng Bu   +3 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Imagem corporal em homens: instrumentos avaliativos

Psicologia: Teoria e Pesquisa
Este estudo teve como objetivo avaliar os instrumentos disponíveis para avaliação da imagem corporal de adultos do sexo masculino, bem como verificar as qualidades psicométricas avaliadas no processo de criação/adaptação destes.
Pedro Henrique Berbert de Carvalho, Maria Elisa Caputo Ferreira   +1 more
doaj   +1 more source

A stochastic immersed boundary method for fluid-structure dynamics at microscopic length scales [PDF]

, 2007
Paul J. Atzberger, Peter R. Kramer, Charles S. Peskin   +2 more
openalex   +1 more source

Measurement properties of UCLA Activity Scale for hip and knee arthroplasty patients and translation and cultural adaptation into Danish [PDF]

, 2021
Anne Mørup‐Petersen, Søren Thorgaard Skou, Christina Enciso Holm, Pætur Mikal Holm, Claus Varnum, Michael R. Krogsgaard, Mogens Berg Laursen, Anders Odgaard   +7 more
openalex   +1 more source