Results 51 to 60 of about 4,075,667 (324)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Design and investigation of dual-axis electrostatic driving MEMS scanning micromirror

International Journal of Optomechatronics
Micro-electro-mechanical system (MEMS) is once proposed in 1970s and evolving rapidly. Current researchers are seeking for better designs and better applications for MEMS actuators.
Longqin Wu, Yu-Sheng Lin
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Miniaturized optical module for projection of arbitrary images based on two-dimensional resonant micro scanning mirrors

, 2022
S.72-83This contribution presents an optical module for projection of still images and video sequences. It consists of a laser source, miniature collimator optics, and a special MEMS device, a two-dimensional resonant micro scanning mirror.
Schneider, B., Scholles, M., Jung, E., Lakner, H., Höfer, B., Gerwig, C., Schenk, H., Wolter, A., Frommhagen, K., Bräuer, A., Schreiber, P.   +10 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Model-Based Angular Scan Error Correction of an Electrothermally-Actuated MEMS Mirror

Sensors, 2015
In this paper, the actuation behavior of a two-axis electrothermal MEMS (Microelectromechanical Systems) mirror typically used in miniature optical scanning probes and optical switches is investigated.
Hao Zhang, Dacheng Xu, Xiaoyang Zhang, Qiao Chen, Huikai Xie, Suiqiong Li   +5 more
doaj   +1 more source

A rotating-mirror scanning camera system for light-sheet microscopy

, 2015
We report a rotating-mirror scanning camera system based on a galvanometer and a CCD camera. This system improves the imaging speed by placing a series of paralleled images on the sensor of the camera so that multiple images are acquired during one ...
Li, Runze, Runze Li, Yang, Yanlong, Xing Zhou, Yao, Baoli, Di Wu, Yanlong Yang, Baoli Yao, Ye, Tong, Tong Ye, Wu, Di, Zhou, Xing   +11 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

A Two-Axis Water-Immersible Micro Scanning Mirror Driven by Single Inductor Coil through Dynamic Structural Filtering

Sensors and Actuators A-Physical, 2018
In this paper, we report a new electromagnetic two-axis water-immersible scanning mirrors driven by a single inductor coil and its application in 3D scanning ultrasound microscopic imaging.
Song Xu, Xiaoyu Duan, J. Zou
semanticscholar   +1 more source