Results 201 to 210 of about 4,657 (242)

Structural basis for sterol sensing by Scap and Insig [PDF]

open access: yesCell Reports, 2021
Abstract The sterol regulatory element-binding protein (SREBP) pathway senses the cellular cholesterol level through sterol regulated association between Scap and Insig. Despite the recent structural determination of the transmembrane domains of human Scap and Insig-2 bound to 25-hydroxycholesterol (25HC), the structure and regulatory ...
Pingping Cao, Chuangye Yan, Hongwu Qian
exaly   +4 more sources

Retrospective on Cholesterol Homeostasis: The Central Role of Scap [PDF]

open access: yesAnnual Review of Biochemistry, 2018
Scap is a polytopic membrane protein that functions as a molecular machine to control the cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory discovered Scap, we have learned how it binds sterol regulatory element-binding proteins (SREBPs) and transports them from the endoplasmic reticulum (ER) to the Golgi for ...
Michael Stuart Brown   +2 more
exaly   +3 more sources

Cap CASP, not SCAP, to fight steatohepatitis

Cell Metabolism, 2022
Hepatic lipid synthesis through SREBP has recently been found to be regulated not only through the canonical pathway involving SCAP in response to sterol deficiency, but also through the PIDDosome and CASP2. In this issue, Kim et al. identify a novel interaction between these two pathways in diet-induced non-alcoholic steatohepatitis.
openaire   +2 more sources

Regulation of gene expression by SREBP and SCAP

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000
Sterol regulatory element binding proteins (SREBPs) function as transcription factors that activate specific genes involved in cholesterol synthesis, endocytosis of low density lipoproteins, the synthesis of both saturated and unsaturated fatty acids and glucose metabolism.
P A, Edwards   +3 more
openaire   +2 more sources

SCAP Composer

Balisage Series on Markup Technologies, 2019
The Security Content Automation Protocol (SCAP) schema for source data stream collections standardizes the requirements for packaging Extensible Markup Language (XML) security content into bundles for easy deployment. SCAP bundles must be self-contained such that each bundle contains all necessary information without external references, and reversible
openaire   +1 more source

Scap

Proceedings of the 2013 conference on Internet measurement conference, 2013
Many network monitoring applications must analyze traffic beyond the network layer to allow for connection-oriented analysis, and achieve resilience to evasion attempts based on TCP segmentation. However, existing network traffic capture frameworks provide applications with just raw packets, and leave complex operations like flow tracking and TCP ...
Antonis Papadogiannakis   +2 more
openaire   +2 more sources

SCAP Steps In

1996
Abstract In chapter 3, we saw that Japan had started down the path of script reform, albeit fitfully, long before the Occupation. Both the press and the government were prepared to limit the number of kanji in general use. The press had already voluntarily begun to reduce the use of furigana, which indirectly established a lower limit
openaire   +1 more source

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