Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges
Biomedicines, 2023 Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth.
Qi Liu, Yuan Gao, Jinzhi He
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WIF1 enhanced dentinogenic differentiation in stem cells from apical papilla [PDF]
BMC Oral Health, 2019 Background Odontogenic mesenchymal stem cells (MSCs) isolated from tooth tissues are a reliable resource that can be utilized for dental tissue regeneration.
Haifeng Wang, Yu Cao
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Journal of Oral Biology and Craniofacial Research, 2021 Although dental pulp and apical papilla are originated from neural crest cells, these tissues exhibit distinct characteristics. Notch signaling is one of the known signaling pathways regulating stemness and behaviors of stem cells.
Damrong Damrongsri +4 more
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Effects of iRoot SP on osteogenic differentiation of human stem cells from apical papilla [PDF]
BMC Oral Health, 2021 Background Research shows that nano-bioceramics can modulate the differentiation of dental stem cells. The novel ready-to-use calcium-silicate-based root-canal sealer iRoot SP is widely used in root filling.
Laidi Wu +6 more
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INFLUENCE OF STORAGE MEDIA ON THE VITALITY OF STEM CELLS FROM APICAL PAPILLA [PDF]
Journal of IMAB, 2018 Purpose: Immediate replantation is the treatment of choice for avulsed permanent teeth. Transportation of avulsed teeth to the dentist office requires storage in suitable media, thus keeping periodontal and periapical tissues viable.
Krasimir Hristov +4 more
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Basic Fibroblast Growth Factor Enhances Stemness of Human Stem Cells from the Apical Papilla [PDF]
Journal of Endodontics, 2012 Stem cells from the apical papilla (SCAP) are a type of mesenchymal stem cells found in the developing tissue, apical papilla, of immature permanent teeth. Studies have shown that SCAP are likely to be a source of primary odontoblasts that are responsible for the formation of root dentin.
George T-J Huang, Wenxi He, Longxing Ni
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Simvastatin modulates osteogenic differentiation in Stem Cells isolated from Apical Papilla
BMC Oral HealthBackground Simvastatin modulates numerous stem cell functions, including stemness maintenance and differentiation. The present study aimed to explore the effect of simvastatin on the osteogenic differentiation of Stem Cells isolated from Apical Papilla ...
Paak Rewthamrongsris +6 more
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A pilot study on biological characteristics of human CD24(+) stem cells from the apical papilla
Journal of Dental Sciences, 2022 Background/purpose: CD24 is a specific cell surface marker for undifferentiated dental stem cells from apical papilla (SCAPs) seen only during root development, before the tooth emerges through gum.
Jing Liang +5 more
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Influence of Citric Acid on the Vitality of Stem Cells from Apical Papilla
Acta Medica Bulgarica, 2018 The endodontic treatment of immature permanent teeth with necrotic pulp is a serious clinical challenge. The chemical agents, used in regenerative procedures, should be selected not only based on their bactericidal/bacteriostatic properties, but also on ...
Hristov Kr. +5 more
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Stem cells from tooth apical papilla modulate fibromyalgia-like changes in mice
Brain Research BulletinBackground: The treatment of fibromyalgia remains a current challenge. While the analgesic effects of mesenchymal stem cells have been the subject of previous research, their potential in managing fibromyalgia symptoms needs further investigation.
Ana P.A. Dagnino +3 more
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