Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges
Biomedicines, 2023 Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth.
Qi Liu, Yuan Gao, Jinzhi He
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WIF1 enhanced dentinogenic differentiation in stem cells from apical papilla [PDF]
BMC Oral Health, 2019 Background Odontogenic mesenchymal stem cells (MSCs) isolated from tooth tissues are a reliable resource that can be utilized for dental tissue regeneration.
Haifeng Wang, Yu Cao
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Effects of iRoot SP on osteogenic differentiation of human stem cells from apical papilla [PDF]
BMC Oral Health, 2021 Background Research shows that nano-bioceramics can modulate the differentiation of dental stem cells. The novel ready-to-use calcium-silicate-based root-canal sealer iRoot SP is widely used in root filling.
Laidi Wu +6 more
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The Effect of Liquid-Phase Exfoliated Graphene Film on Neurodifferentiation of Stem Cells from Apical Papilla [PDF]
Nanomaterials, 2022 Background: Dental stem cells, which originate from the neural crest, due to their easy accessibility might be good candidates in neuro-regenerative procedures, along with graphene-based nanomaterials shown to promote neurogenesis in vitro.
Jelena Simonovic +7 more
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Journal of Oral Biology and Craniofacial Research, 2021 Although dental pulp and apical papilla are originated from neural crest cells, these tissues exhibit distinct characteristics. Notch signaling is one of the known signaling pathways regulating stemness and behaviors of stem cells.
Damrong Damrongsri +4 more
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Potential of resveratrol in enrichment of neural progenitor-like cell induction of human stem cells from apical papilla [PDF]
Stem Cell Research & Therapy, 2020 Introduction Stem cell transplantation of exogenous neural progenitor cells (NPCs) derived from mesenchymal stem cells (MSCs) has emerged as a promising approach for neurodegenerative disease.
Anupong Songsaad +4 more
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Hypoxic stem cells from apical papilla-derived exosomes enhance dental pulp stem cells migration and differentiation via mitochondrial activation [PDF]
Journal of Dental SciencesBackground/purpose: Stem cells from apical papilla (SCAPs) and dental pulp stem cells (DPSCs) play critical roles in dental tissue regeneration. Although intercellular communication through exosomes is known to influence stem cell regulation, the effects
Deyan Yuan, Rui Tao, Bi Yin, Meng Gu
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Characterization of neural stem cells derived from human stem cells from the apical papilla undergoing three-dimensional neurosphere induction [PDF]
Journal of Applied Oral Science, 2023 Objectives The endogenous repairing based on the activation of neural stem cells (NSCs) is impaired by neurodegenerative diseases. The present study aims to characterize human stem cells from the apical papilla (hSCAPs) with features of mesenchymal stem
Anupong Thongklam SONGSAAD +9 more
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DLX5 and HOXC8 enhance the chondrogenic differentiation potential of stem cells from apical papilla via LINC01013 [PDF]
Stem Cell Research & Therapy, 2020 Background Mesenchymal stem cell (MSC)-based cartilage tissue regeneration is a treatment with great potential. How to enhance the MSC chondrogenic differentiation is a key issue involved in cartilage formation.
Haoqing Yang +9 more
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Conversion of stem cells from apical papilla into endothelial cells by small molecules and growth factors. [PDF]
Stem Cell Res Ther, 2021 Abstract Objectives Recently, a new strategy has been developed to directly reprogram one cell type towards another targeted cell type using small molecule compounds. Human fibroblasts have been chemically reprogrammed into neuronal cells, Schwann cells and cardiomyocyte-like cells by different small molecule ...
Yi B +8 more
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