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Neural Regenerative Potential of Stem Cells Derived from the Tooth Apical Papilla [PDF]
Stem Cells and Development, 2020 The regenerative effects of stem cells derived from dental tissues have been previously investigated. This study assessed the potential of human tooth stem cells from apical papilla (SCAP) on nerve regeneration. The SCAP collected from nine individuals were characterized and polarized by exposure to interferon-γ (IFN-γ).
Ana Paula Aquistapase, Dagnino +8 more
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Mesenchymal stem cell-mediated functional tooth regeneration in swine. [PDF]
PLoS ONE, 2006 Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells ...
Wataru Sonoyama +10 more
doaj +1 more source
Effect of Long-Term Cryopreservation on the Stemness of Stem Cells of Apical Papilla
International Journal of Dentistry, 2022 Stem cells of apical papilla (SCAPs) are considered a subpopulation of dental stem cells with unique properties. They originate from a developing tissue, the apical papilla of developing teeth, a characteristic that enhances their stemness.
Anna Digka +3 more
doaj +1 more source
Stem Cells from the Apical Papilla: A Promising Source for Stem Cell-Based Therapy
BioMed Research International, 2019 Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can be used as an alternative to ...
Jun Kang +4 more
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Frontiers in Cell and Developmental Biology, 2023 Stem cells from the apical papilla (SCAPs) are promising candidates for regenerative endodontic treatment and tissue regeneration in general. However, harvesting enough cells from the limited apical papilla tissue is difficult, and the cells lose their ...
Qianyu Cheng +14 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Objective: Indirect Jagged1 immobilization efficiently activates canonical Notch signaling in human dental pulp stem cells (hDPSCs). This study aimed to investigate the characteristics of the Jagged1-treated hDPSC-derived decellularized extracellular ...
Suphalak Phothichailert +9 more
doaj +1 more source
Biomaterials and Scaffold Design Strategies for Regenerative Endodontic Therapy
Frontiers in Bioengineering and Biotechnology, 2019 Challenges with traditional endodontic treatment for immature permanent teeth exhibiting pulp necrosis have prompted interest in tissue engineering approaches to regenerate the pulp-dentin complex and allow root development to continue.
Gavin Raddall +3 more
doaj +1 more source
Journal of Clinical and Experimental Dentistry, 2021 Dental Mesenchymal stem cells has prompted great for cell-based therapeutics. But no one knows for sure what the true potential of these cells, since most of the studies were done in isolation, using as source, different donors or different cell processing conditions.An enriched population of cells positive for CD146, STRO-1, and CD90 was isolated of ...
Rezende, Karla Mayra P. C. +6 more
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International Endodontic Journal, 2023 AbstractAimTo establish and fully characterize a new cell line from human stem cells of the apical papilla (SCAPs) through immortalization with an SV40 large T antigen.MethodologyHuman SCAPs were isolated and transfected with an SV40 large T antigen and treated with puromycin to select the infected population.
Diana Sanz‐Serrano +3 more
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Effects of ethylenediaminetetraacetic acid on stem cells from the apical papilla: In vitro study
Journal of Dental Sciences, 2023 Ethylenediaminetetraacetic acid (EDTA) is used as an irrigant in regenerative endodontic treatment. The present study aimed to investigate the effects of EDTA on stem cells from apical papilla (SCAPs) in vitro.Human SCAPs were isolated and characterised. The cells were treated with media supplemented with EDTA at concentrations ranging from 1.25% to 17%
Suphalak Phothichailert +6 more
openaire +4 more sources