Results 31 to 40 of about 4,117 (183)

[Inhibition of autophagy suppresses osteogenic differentiation of stem cells from apical papilla]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao, 2019
To investigate the effects of autophagy on osteogenic differentiation of stem cells from the apical papilla (SCAPs) in the presence of tumor necrosis factor-α (TNF-α) stimulation in vitro.SCAPs treated with TNF-α (0, 5, and 10 ng/mL) with or without 5 mmol/L 3-MA were examined for the expression of autophagy marker LC3-Ⅱ using Western blotting.
Huang Y, Xiong H, Chen K, Zhu X, Yin X, Liang Y, Luo W, Lei Q.   +7 more
europepmc   +3 more sources

Effects of ethylenediaminetetraacetic acid on stem cells from the apical papilla: In vitro study

Journal of Dental Sciences, 2023
Ethylenediaminetetraacetic acid (EDTA) is used as an irrigant in regenerative endodontic treatment. The present study aimed to investigate the effects of EDTA on stem cells from apical papilla (SCAPs) in vitro.Human SCAPs were isolated and characterised. The cells were treated with media supplemented with EDTA at concentrations ranging from 1.25% to 17%
Suphalak Phothichailert, Benya Sangwisutsai, Dhitinant Rattanakosol, Nutcha Teerapongpaibul, Sirawut Hiran-us, Nunthawan Nowwarote, Thanaphum Osathanon   +6 more
openaire   +6 more sources

Mesenchymal stem cell-mediated functional tooth regeneration in swine. [PDF]

PLoS ONE, 2006
Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells ...
Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung-Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun-Yu Wang, Songlin Wang, Songtao Shi   +10 more
doaj   +1 more source

Stem Cells from the Apical Papilla: A Promising Source for Stem Cell-Based Therapy

BioMed Research International, 2019
Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can be used as an alternative to ...
Jun Kang, Wenguo Fan, Qianyi Deng, Hongwen He, Fang Huang   +4 more
openaire   +3 more sources

Effect of Long-Term Cryopreservation on the Stemness of Stem Cells of Apical Papilla

International Journal of Dentistry, 2022
Stem cells of apical papilla (SCAPs) are considered a subpopulation of dental stem cells with unique properties. They originate from a developing tissue, the apical papilla of developing teeth, a characteristic that enhances their stemness.
Anna Digka, Eleni Gounari, Kokkona Kouzi-Koliakou, Kleoniki Lyroudia   +3 more
doaj   +1 more source

Establishing and characterizing human stem cells from the apical papilla immortalized by hTERT gene transfer

Frontiers in Cell and Developmental Biology, 2023
Stem cells from the apical papilla (SCAPs) are promising candidates for regenerative endodontic treatment and tissue regeneration in general. However, harvesting enough cells from the limited apical papilla tissue is difficult, and the cells lose their ...
Qianyu Cheng, Qianyu Cheng, Qianyu Cheng, Qianyu Cheng, Chang Liu, Chang Liu, Chang Liu, Chang Liu, Qiuman Chen, Wenping Luo, Tong-Chuan He, Deqin Yang, Deqin Yang, Deqin Yang, Deqin Yang   +14 more
doaj   +1 more source

Effects of decellularized extracellular matrix derived from Jagged1-treated human dental pulp stem cells on biological responses of stem cells isolated from apical papilla

Frontiers in Cell and Developmental Biology, 2022
Objective: Indirect Jagged1 immobilization efficiently activates canonical Notch signaling in human dental pulp stem cells (hDPSCs). This study aimed to investigate the characteristics of the Jagged1-treated hDPSC-derived decellularized extracellular ...
Suphalak Phothichailert, Nunthawan Nowwarote, Nunthawan Nowwarote, Benjamin P.J. Fournier, Benjamin P.J. Fournier, Vorapat Trachoo, Sittiruk Roytrakul, Worachat Namangkalakul, Thanaphum Osathanon, Thanaphum Osathanon   +9 more
doaj   +1 more source

Effect of Biodentine Coated with Emdogain on Proliferation and Differentiation of Stem Cells from the Apical Papilla [PDF]

Molecular Biology Reports, 2021
Abstract Background: This study assessed the effect of Biodentine coated with Emdogain (Biodentine/Emdogain) on proliferation and differentiation of stem cells from the apical papilla (SCAP). Methods and Results: In this in vitro, experimental study, SCAP were isolated from two immature impacted third molars and cultured.
Hamed Karkehabadi, Erfan Ahmadyani, Rezvan Najafi, Elham Khoshbin   +3 more
openaire   +2 more sources

Characterization of neural stem cells derived from human stem cells from the apical papilla undergoing three-dimensional neurosphere induction [PDF]

Journal of Applied Oral Science, 2023
Objectives The endogenous repairing based on the activation of neural stem cells (NSCs) is impaired by neurodegenerative diseases. The present study aims to characterize human stem cells from the apical papilla (hSCAPs) with features of mesenchymal stem
Anupong Thongklam SONGSAAD, Sarut THAIRAT, Peeratchai SEEMAUNG, Amarin THONGSUK, Tatcha BALIT, Nisarat RUANGSAWASDI, Chareerut PHRUKSANIYOM, Thanasup GONMANEE, Kenneth L. WHITE, Charoensri THONABULSOMBAT   +9 more
doaj   +1 more source

Biomaterials and Scaffold Design Strategies for Regenerative Endodontic Therapy

Frontiers in Bioengineering and Biotechnology, 2019
Challenges with traditional endodontic treatment for immature permanent teeth exhibiting pulp necrosis have prompted interest in tissue engineering approaches to regenerate the pulp-dentin complex and allow root development to continue.
Gavin Raddall, Isabel Mello, Brendan M. Leung, Brendan M. Leung   +3 more
doaj   +1 more source