Results 1 to 10 of about 870 (134)

Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges

Biomedicines, 2023
Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth.
Qi Liu, Yuan Gao, Jinzhi He
doaj   +5 more sources

Exploring the potential of stem cells from the apical papilla (SCAPs) in regenerative medicine: advantages, applications, challenges and opportunities [PDF]

Stem Cell Research & Therapy
Stem cells from the apical papilla (SCAPs) represent a unique population of mesenchymal stem cells (MSCs) located in the apical papilla of immature permanent teeth.
Mengyu Huang, Waruna Lakmal Dissanayaka, Cynthia KY YIU   +2 more
doaj   +4 more sources

Combination of Dental Capping Agents With LowLevel Laser Therapy Increases the Cell Viability Percent of Stem Cells From Apical Papilla (SCAPs). [PDF]

J Lasers Med Sci, 2022
Introduction: Dental pulp capping is a technique that is highly applicable in dental restorations. In this technique, a material is directly placed over the exposed pulp tissue, which promotes pulp healing and generates reparative dentin. Herein, we aimed to investigate the combined effect of different pulp capping agents, including mineral trioxide ...
Zafari J, Karkehabadi H, Nikzad F, Esmailnasab S, Abbasi Javan Z, Javani Jouni F.   +5 more
europepmc   +3 more sources

Differential expression of Notch related genes in dental pulp stem cells and stem cells isolated from apical papilla

Journal of Oral Biology and Craniofacial Research, 2021
Although dental pulp and apical papilla are originated from neural crest cells, these tissues exhibit distinct characteristics. Notch signaling is one of the known signaling pathways regulating stemness and behaviors of stem cells.
Damrong Damrongsri, Nunthawan Nowwarote, Opor Sonpoung, Suphalak Photichailert, Thanaphum Osathanon   +4 more
doaj   +3 more sources

The Journey of SCAPs (Stem Cells from Apical Papilla), from Their Native Tissue to Grafting: Impact of Oxygen Concentration

Cells, 2022
Tissue engineering strategies aim at characterizing and at optimizing the cellular component that is combined with biomaterials, for improved tissue regeneration.
Marine Mavinga, Mathilde Palmier, Murielle Rémy, Caroline Jeannière, Solène Lenoir, Sylvie Rey, Martine Saint-Marc, Florian Alonso, Elisabeth Génot, Noélie Thébaud, Edith Chevret, Virginie Mournetas, Benoit Rousseau, Claudine Boiziau, Helene Boeuf   +14 more
doaj   +5 more sources

Schisantherin A promotes neural differentiation of stem cells from apical papilla to improve mandibular development via mental nerve repair [PDF]

Stem Cell Research & Therapy
Background Evidence shows neural involvement in bone remodeling; regulating maxillofacial nerve repair modulates jawbone. Neural stem cell (NSC) therapy is limited by sources/ethics, but neural crest-derived dental mesenchymal stem cells (MSCs) like stem
Lingxi Du, Ailian Li, Ziling Tang, Hanxiang Yang, Xinyu Shi, Shengchao Wang, Zuocheng Qiu, Xuesong Yang, Yue Huang   +8 more
doaj   +2 more sources

Hypoxic stem cells from apical papilla-derived exosomes enhance dental pulp stem cells migration and differentiation via mitochondrial activation [PDF]

Journal of Dental Sciences
Background/purpose: Stem cells from apical papilla (SCAPs) and dental pulp stem cells (DPSCs) play critical roles in dental tissue regeneration. Although intercellular communication through exosomes is known to influence stem cell regulation, the effects
Deyan Yuan, Rui Tao, Bi Yin, Meng Gu
doaj   +2 more sources

Notch2 is involved in regulating apical tissue repair following severe intrusive luxation [PDF]

Journal of Applied Oral Science
This study aims to characterize apical repair dynamics in immature permanent teeth after severe intrusive luxation, and to explore Notch signaling pathway regulation in this process using a Sprague-Dawley rat model.
Yuanpei He, Xuyan Gong, Cancan Ding, Yang Qiu, Guangwen Li, Shiting Li   +5 more
doaj   +3 more sources

Prolonged high-density culture with restricted medium renewal induces epithelial-like plasticity in apical papilla stem cells [PDF]

Biomolecules & Biomedicine
Stem cells from the apical papilla (SCAPs) are dental mesenchymal stem cells known for their high proliferative and multilineage potential. However, prolonged in vitro expansion may alter their phenotype due to microenvironmental stress.
Kameliya Kercheva, Marina Miteva, Silvia Kalenderova, Vanyo Mitev, Zornitsa Mihaylova, Nikolay Ishkitiev, Violeta S. Dimitrova   +6 more
doaj   +2 more sources

Protein Arginine Methyltransferase 6 Regulated Odontogenic Differentiation and Mitochondrial Function of Stem Cells from Apical Papilla Through its Nuclear Localization Sequence via β-catenin Pathway [PDF]

International Dental Journal
Objectives: Odontogenic differentiation of stem cells from apical papilla (SCAPs) is critical for pulp regeneration therapy. Protein arginine methyltransferase 6 (PRMT6) plays an important role in stem cell differentiation, but the specific functions and
Wanhao Yan, Xiaoli Guo, Bingqi Zhao, Yongkang Li, Zhe Shen, Ruitang Shi, Chen Zhang   +6 more
doaj   +2 more sources