Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges [PDF]
Biomedicines, 2023 Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth.
Qi Liu, Yuan Gao, Jinzhi He
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Characterization of neural stem cells derived from human stem cells from the apical papilla undergoing three-dimensional neurosphere induction [PDF]
Journal of Applied Oral Science, 2023 Objectives The endogenous repairing based on the activation of neural stem cells (NSCs) is impaired by neurodegenerative diseases. The present study aims to characterize human stem cells from the apical papilla (hSCAPs) with features of mesenchymal stem
Anupong Thongklam SONGSAAD +9 more
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Establishing and characterizing human stem cells from the apical papilla immortalized by hTERT gene transfer [PDF]
Frontiers in Cell and Developmental Biology, 2023 Stem cells from the apical papilla (SCAPs) are promising candidates for regenerative endodontic treatment and tissue regeneration in general. However, harvesting enough cells from the limited apical papilla tissue is difficult, and the cells lose their ...
Qianyu Cheng +14 more
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A pilot study on biological characteristics of human CD24(+) stem cells from the apical papilla [PDF]
Journal of Dental Sciences, 2022 Background/purpose: CD24 is a specific cell surface marker for undifferentiated dental stem cells from apical papilla (SCAPs) seen only during root development, before the tooth emerges through gum.
Jing Liang +5 more
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Stem Cells From the Apical Papilla (SCAP) as a Tool for Endogenous Tissue Regeneration [PDF]
Frontiers in Bioengineering and Biotechnology, 2018 Stem cells extracted from developing tissues possibly exhibit not only unique but also superior traits against their developed counterparts. Indeed, stem cells from the apical papilla (SCAP); a unique group of dental stem cells related to developing ...
Ola A. Nada +3 more
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Exosomes Derived from Stem Cells from the Apical Papilla Promote Dentine-Pulp Complex Regeneration by Inducing Specific Dentinogenesis [PDF]
Stem Cells International, 2020 Regenerative endodontic procedures (REPs) are a new option for the treatment of dental pulp or periapical diseases in permanent teeth with open apices. Histologically, the new tissues formed in the root canal after REPs are mainly cementum- or bone-like ...
Xueying Zhuang +8 more
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Exploring the potential of stem cells from the apical papilla (SCAPs) in regenerative medicine: advantages, applications, challenges and opportunities [PDF]
Stem Cell Research & TherapyStem cells from the apical papilla (SCAPs) represent a unique population of mesenchymal stem cells (MSCs) located in the apical papilla of immature permanent teeth.
Mengyu Huang +2 more
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Schisantherin A promotes neural differentiation of stem cells from apical papilla to improve mandibular development via mental nerve repair [PDF]
Stem Cell Research & TherapyBackground Evidence shows neural involvement in bone remodeling; regulating maxillofacial nerve repair modulates jawbone. Neural stem cell (NSC) therapy is limited by sources/ethics, but neural crest-derived dental mesenchymal stem cells (MSCs) like stem
Lingxi Du +8 more
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EVALUATION OF THE ADHESION AND MORPHOLOGY OF STEM CELLS FROM APICAL PAPILLA IN DIRECT CONTACT WITH MTA AND BIODENTINE [PDF]
Journal of IMAB, 2022 Purpose: To investigate the use of tricalcium silicate cement Biodentine as an alternative to MTA in regenerative endodontic procedures by assessing the morphology and adhesion of stem cells from apical papilla in direct contact with these materials ...
Krasimir Hristov +3 more
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Journal of Oral Biology and Craniofacial Research, 2021 Although dental pulp and apical papilla are originated from neural crest cells, these tissues exhibit distinct characteristics. Notch signaling is one of the known signaling pathways regulating stemness and behaviors of stem cells.
Damrong Damrongsri +4 more
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