International Endodontic Journal, 2023 AbstractAimTo establish and fully characterize a new cell line from human stem cells of the apical papilla (SCAPs) through immortalization with an SV40 large T antigen.MethodologyHuman SCAPs were isolated and transfected with an SV40 large T antigen and treated with puromycin to select the infected population.
Diana Sanz‐Serrano +3 more
openaire +3 more sources
Basic Fibroblast Growth Factor Enhances Stemness of Human Stem Cells from the Apical Papilla [PDF]
Journal of Endodontics, 2012 Stem cells from the apical papilla (SCAP) are a type of mesenchymal stem cells found in the developing tissue, apical papilla, of immature permanent teeth. Studies have shown that SCAP are likely to be a source of primary odontoblasts that are responsible for the formation of root dentin.
Jiayuan, Wu +8 more
openaire +2 more sources
Effect of Long-Term Cryopreservation on the Stemness of Stem Cells of Apical Papilla
International Journal of Dentistry, 2022 Stem cells of apical papilla (SCAPs) are considered a subpopulation of dental stem cells with unique properties. They originate from a developing tissue, the apical papilla of developing teeth, a characteristic that enhances their stemness.
Anna Digka +3 more
doaj +1 more source
Journal of Tissue Engineering, 2022 Apical periodontitis (AP) causes arrest of tooth root development, which is associated with impaired odontoblastic differentiation of stem cells from apical papilla (SCAPs), but the underlying mechanism remains unclear.
Shengyan Yang +8 more
doaj +1 more source
Evaluation of the Cytotoxicity of Two Types of Triple Antibiotic Paste on Human Permanent Dental Apical Papilla Stem Cells: an in vitro Study [PDF]
Journal of Dentistry, 2022 Statement of the Problem: The use of a new antimicrobial combination in the regenerative endodontic treatment of immature teeth pulp necrosis is a well-known method.
Rezvan Rafatjou +4 more
doaj +1 more source
Depletion of SNRNP200 inhibits the osteo-/dentinogenic differentiation and cell proliferation potential of stem cells from the apical papilla. [PDF]
BMC Dev Biol, 2020 Abstract Background Tissue regeneration mediated by mesenchymal stem cells (MSCs) is deemed a desirable way to repair teeth and craniomaxillofacial tissue defects. Nevertheless, the molecular mechanisms about cell proliferation and committed differentiation of MSCs remain obscure.
Su X +6 more
europepmc +4 more sources
Stem cells from the dental apical papilla in extracellular matrix hydrogels mitigate inflammation of microglial cells [PDF]
Scientific Reports, 2019 AbstractAfter spinal cord injury (SCI) chronic inflammation hampers regeneration. Influencing the local microenvironment after SCI may provide a strategy to modulate inflammation and the immune response. The objectives of this work were to determine whether bone or spinal cord derived ECM hydrogels can deliver human mesenchymal stem cells from the ...
Natalija Tatic +3 more
openaire +3 more sources
Biomaterials and Scaffold Design Strategies for Regenerative Endodontic Therapy
Frontiers in Bioengineering and Biotechnology, 2019 Challenges with traditional endodontic treatment for immature permanent teeth exhibiting pulp necrosis have prompted interest in tissue engineering approaches to regenerate the pulp-dentin complex and allow root development to continue.
Gavin Raddall +3 more
doaj +1 more source
Molecular insight into odontogenesis in hyperglycemic environment: A systematic review
Journal of Pharmacy and Bioallied Sciences, 2020 Diabetes mellitus is an endocrinal disorder affecting worldwide and the disease incidence is rising alarmingly high. The effects of diabetes on tooth development are explored by limited studies and their molecular insights are very rarely studied.
Andamuthu Yamunadevi +6 more
doaj +1 more source
Potential use of human periapical cyst-mesenchymal stem cells (hPCy-MSCs) as a novel stem cell source for regenerative medicine applications [PDF]
, 2017 Mesenchymal stem cells (MSCs) are attracting growing interest by the scientific community due to their huge regenerative potential. Thus, the plasticity of MSCs strongly suggests the utilization of these cells for regenerative medicine applications.
Codispoti, Bruna +6 more
core +2 more sources