Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges [PDF]
Biomedicines, 2023 Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth.
Qi Liu, Yuan Gao, Jinzhi He
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Does Apical Papilla Survive and Develop in Apical Periodontitis Presence after Regenerative Endodontic Procedures? [PDF]
Applied Sciences, 2019 Regenerative endodontic procedures (REPs) have emerged as a treatment option for immature necrotic teeth to allow the reestablishment of a newly formed vital tissue and enable continued root development.
Paulo J. Palma +6 more
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Simvastatin modulates osteogenic differentiation in Stem Cells isolated from Apical Papilla [PDF]
BMC Oral HealthBackground Simvastatin modulates numerous stem cell functions, including stemness maintenance and differentiation. The present study aimed to explore the effect of simvastatin on the osteogenic differentiation of Stem Cells isolated from Apical Papilla ...
Paak Rewthamrongsris +6 more
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Unraveling the Role of the Apical Papilla During Dental Root Maturation [PDF]
Frontiers in Cell and Developmental Biology, 2021 The apical papilla is a stem cell rich tissue located at the base of the developing dental root and is responsible for the progressive elongation and maturation of the root.
Ronald B. Driesen +3 more
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Bioactivity effects of extracellular matrix proteins on apical papilla cells [PDF]
Journal of Applied Oral Science, 2021 Potent signaling agents stimulate and guide pulp tissue regeneration, especially in endodontic treatment of teeth with incomplete root formation. Objective This study evaluated the bioactive properties of low concentrations of extracellular matrix ...
Maria Luísa LEITE +6 more
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N-Acetylcysteine Protects the Stem Cells of the Apical Papilla
Frontiers in Dental Medicine, 2022 ObjectivePrevious research has demonstrated that stem cells of the apical papilla (SCAP) have a lower differentiation potential and are less resistant to cell death as compared to other stem cells. N-acetyl cysteine (NAC) prevents apoptosis of the dental
Kyle Countryman +3 more
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WIF1 enhanced dentinogenic differentiation in stem cells from apical papilla
BMC Oral Health, 2019 Background Odontogenic mesenchymal stem cells (MSCs) isolated from tooth tissues are a reliable resource that can be utilized for dental tissue regeneration.
Haifeng Wang, Yu Cao
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Effect of Long-Term Cryopreservation on the Stemness of Stem Cells of Apical Papilla [PDF]
International Journal of Dentistry, 2022 Stem cells of apical papilla (SCAPs) are considered a subpopulation of dental stem cells with unique properties. They originate from a developing tissue, the apical papilla of developing teeth, a characteristic that enhances their stemness.
Anna Digka +3 more
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Exploring the potential of stem cells from the apical papilla (SCAPs) in regenerative medicine: advantages, applications, challenges and opportunities [PDF]
Stem Cell Research & TherapyStem cells from the apical papilla (SCAPs) represent a unique population of mesenchymal stem cells (MSCs) located in the apical papilla of immature permanent teeth.
Mengyu Huang +2 more
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Effects of a New Bioceramic Material on Human Apical Papilla Cells [PDF]
Journal of Functional Biomaterials, 2018 Background: The development of materials with bioregenerative properties is critically important for vital pulp therapies and regenerative endodontic procedures.
Diana B. Sequeira +5 more
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