Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges [PDF]
Biomedicines, 2023 Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth.
Jinzhi He
exaly +4 more sources
Unraveling the Role of the Apical Papilla During Dental Root Maturation
Frontiers in Cell and Developmental Biology, 2021 The apical papilla is a stem cell rich tissue located at the base of the developing dental root and is responsible for the progressive elongation and maturation of the root.
Ivo Lambrichts +2 more
exaly +3 more sources
Applied Sciences (Switzerland), 2019 Regenerative endodontic procedures (REPs) have emerged as a treatment option for immature necrotic teeth to allow the reestablishment of a newly formed vital tissue and enable continued root development.
Anibal Diogenes +2 more
exaly +3 more sources
Effect of Long-Term Cryopreservation on the Stemness of Stem Cells of Apical Papilla [PDF]
International Journal of Dentistry, 2022 Stem cells of apical papilla (SCAPs) are considered a subpopulation of dental stem cells with unique properties. They originate from a developing tissue, the apical papilla of developing teeth, a characteristic that enhances their stemness.
Anna Digka +3 more
doaj +2 more sources
Exploring the potential of stem cells from the apical papilla (SCAPs) in regenerative medicine: advantages, applications, challenges and opportunities [PDF]
Stem Cell Research & TherapyStem cells from the apical papilla (SCAPs) represent a unique population of mesenchymal stem cells (MSCs) located in the apical papilla of immature permanent teeth.
Mengyu Huang +2 more
doaj +2 more sources
The Differentiation Potential of Apical Papilla Cells in Relation to Tenascin-C and Syndecan-1 Expression and Their Potential Role in Regeneration [PDF]
International Journal of DentistryConclusions: Cell differentiation potential in the developing swine apex is progressively restricted to the newly formed dental pulp, whereas phenotypic expression of apical papilla cells remains undetermined unless the new microenvironment triggers cell
K. Kodonas +3 more
doaj +2 more sources
Sphingosine-1-phosphate receptor 1-mediated odontogenic differentiation of mouse apical papilla-derived stem cells [PDF]
Journal of Dental SciencesBackground/purpose: Sphingosine-1-phosphate (S1P) exhibits receptor-mediated physiological effects by facilitating the differentiation of mesenchymal stem cells toward the osteoblast lineage. This study aimed to determine the effect of S1P on odontogenic
Haruna Hirose +6 more
doaj +2 more sources
Different concentrations of fetal bovine serum affect cytokine modulation in Lipopolysaccharide-activated apical papilla cells in vitro [PDF]
Journal of Applied Oral Science, 2023 Fetal bovine serum (FBS) is the most used supplement in culture media; however, it may interfere with in vitro assays via effects on cell proliferation and cytokine production.
Letícia Martins SANTOS +4 more
doaj +2 more sources
Histatin-1 promotes the expression of markers associated with odontoblastic differentiation in the dental pulp and apical papilla [PDF]
Scientific ReportsComplex tooth injuries, including dental caries, require the reestablishment of tissue architecture and functionality through the regeneration of cellular populations that enable tertiary dentin formation and the reestablishment of vascular and neural ...
Patricio Silva +10 more
doaj +2 more sources
Wnt-directed CXCL12-expressing apical papilla progenitor cells drive tooth root formation [PDF]
Nature CommunicationsThe tooth root is a critical component of the tooth anchored to surrounding alveolar bones. Tooth root formation is driven by cells in the apical papilla (AP) that generate new dentin-forming odontoblasts at the root-forming front. Mesenchymal stem cells
Mizuki Nagata +16 more
doaj +2 more sources