Stem Cells from the Apical Papilla (SCAPs): Past, Present, Prospects, and Challenges [PDF]
Biomedicines, 2023 Dental diseases occurring on young permanent teeth usually lead to the premature arrest of tooth root development. Sustained tooth root elongation is necessary to achieve the goal of long-term preservation of affected teeth.
Jinzhi He
exaly +8 more sources
Unraveling the Role of the Apical Papilla During Dental Root Maturation [PDF]
Frontiers in Cell and Developmental Biology, 2021 The apical papilla is a stem cell rich tissue located at the base of the developing dental root and is responsible for the progressive elongation and maturation of the root.
Ivo Lambrichts +2 more
exaly +9 more sources
Does Apical Papilla Survive and Develop in Apical Periodontitis Presence after Regenerative Endodontic Procedures? [PDF]
Applied Sciences (Switzerland), 2019 Regenerative endodontic procedures (REPs) have emerged as a treatment option for immature necrotic teeth to allow the reestablishment of a newly formed vital tissue and enable continued root development.
Anibal Diógenes +2 more
exaly +10 more sources
Effect of Long-Term Cryopreservation on the Stemness of Stem Cells of Apical Papilla [PDF]
International Journal of Dentistry, 2022 Stem cells of apical papilla (SCAPs) are considered a subpopulation of dental stem cells with unique properties. They originate from a developing tissue, the apical papilla of developing teeth, a characteristic that enhances their stemness.
Anna Digka +3 more
doaj +6 more sources
Simvastatin modulates osteogenic differentiation in Stem Cells isolated from Apical Papilla [PDF]
BMC Oral HealthBackground Simvastatin modulates numerous stem cell functions, including stemness maintenance and differentiation. The present study aimed to explore the effect of simvastatin on the osteogenic differentiation of Stem Cells isolated from Apical Papilla ...
Paak Rewthamrongsris +6 more
doaj +6 more sources
Bioactivity effects of extracellular matrix proteins on apical papilla cells [PDF]
Journal of Applied Oral Science, 2021 Potent signaling agents stimulate and guide pulp tissue regeneration, especially in endodontic treatment of teeth with incomplete root formation. Objective This study evaluated the bioactive properties of low concentrations of extracellular matrix ...
Maria Luísa LEITE +6 more
doaj +10 more sources
WIF1 enhanced dentinogenic differentiation in stem cells from apical papilla [PDF]
BMC Oral Health, 2019 Background Odontogenic mesenchymal stem cells (MSCs) isolated from tooth tissues are a reliable resource that can be utilized for dental tissue regeneration.
Haifeng Wang, Yu Cao
doaj +4 more sources
Sphingosine-1-phosphate receptor 1-mediated odontogenic differentiation of mouse apical papilla-derived stem cells [PDF]
Journal of Dental SciencesBackground/purpose: Sphingosine-1-phosphate (S1P) exhibits receptor-mediated physiological effects by facilitating the differentiation of mesenchymal stem cells toward the osteoblast lineage. This study aimed to determine the effect of S1P on odontogenic
Haruna Hirose +6 more
doaj +4 more sources
Molecular Biological Comparison of Dental Pulp- and Apical Papilla-Derived Stem Cells [PDF]
International Journal of Molecular Sciences, 2022 Both the dental pulp and the apical papilla represent a promising source of mesenchymal stem cells for regenerative endodontic protocols. The aim of this study was to outline molecular biological conformities and differences between dental pulp stem cells (DPSC) and stem cells from the apical papilla (SCAP).
Matthias Widbiller +2 more
exaly +8 more sources
Exploring the potential of stem cells from the apical papilla (SCAPs) in regenerative medicine: advantages, applications, challenges and opportunities [PDF]
Stem Cell Research & TherapyStem cells from the apical papilla (SCAPs) represent a unique population of mesenchymal stem cells (MSCs) located in the apical papilla of immature permanent teeth.
Mengyu Huang +2 more
doaj +3 more sources