Results 11 to 20 of about 17,760 (286)

Molecular Biological Comparison of Dental Pulp- and Apical Papilla-Derived Stem Cells [PDF]

International Journal of Molecular Sciences, 2022
Both the dental pulp and the apical papilla represent a promising source of mesenchymal stem cells for regenerative endodontic protocols. The aim of this study was to outline molecular biological conformities and differences between dental pulp stem cells (DPSC) and stem cells from the apical papilla (SCAP).
Smeda, Martyna, Galler, Kerstin M., Woelflick, Melanie, Rosendahl, Andreas, Moehle, Christoph, Lenhardt, Beate, Buchalla, Wolfgang, Widbiller, Matthias   +7 more
openaire   +6 more sources

Establishing and characterizing human stem cells from the apical papilla immortalized by hTERT gene transfer [PDF]

Frontiers in Cell and Developmental Biology, 2023
Stem cells from the apical papilla (SCAPs) are promising candidates for regenerative endodontic treatment and tissue regeneration in general. However, harvesting enough cells from the limited apical papilla tissue is difficult, and the cells lose their ...
Qianyu Cheng, Qianyu Cheng, Qianyu Cheng, Qianyu Cheng, Chang Liu, Chang Liu, Chang Liu, Chang Liu, Qiuman Chen, Wenping Luo, Tong-Chuan He, Deqin Yang, Deqin Yang, Deqin Yang, Deqin Yang   +14 more
doaj   +2 more sources

Sphingosine-1-phosphate receptor 1-mediated odontogenic differentiation of mouse apical papilla-derived stem cells [PDF]

Journal of Dental Sciences
Background/purpose: Sphingosine-1-phosphate (S1P) exhibits receptor-mediated physiological effects by facilitating the differentiation of mesenchymal stem cells toward the osteoblast lineage. This study aimed to determine the effect of S1P on odontogenic
Haruna Hirose, Seishiro Fujimasa, Shingo Kanemaru, Shohei Yoshimoto, Noriyoshi Matsumoto, Hisashi Anan, Etsuko Matsuzaki   +6 more
doaj   +2 more sources

The Differentiation Potential of Apical Papilla Cells in Relation to Tenascin-C and Syndecan-1 Expression and Their Potential Role in Regeneration [PDF]

International Journal of Dentistry
Conclusions: Cell differentiation potential in the developing swine apex is progressively restricted to the newly formed dental pulp, whereas phenotypic expression of apical papilla cells remains undetermined unless the new microenvironment triggers cell
K. Kodonas, A. Fardi, S. Papadimitriou, C. Gogos   +3 more
doaj   +2 more sources

Different concentrations of fetal bovine serum affect cytokine modulation in Lipopolysaccharide-activated apical papilla cells in vitro [PDF]

Journal of Applied Oral Science, 2023
Fetal bovine serum (FBS) is the most used supplement in culture media; however, it may interfere with in vitro assays via effects on cell proliferation and cytokine production.
Letícia Martins SANTOS, Patricia e Silva CARDOSO, Elisa Abreu DINIZ, Juliana Garuba RAHHAL, Carla Renata SIPERT   +4 more
doaj   +2 more sources

Wnt-directed CXCL12-expressing apical papilla progenitor cells drive tooth root formation [PDF]

Nature Communications
The tooth root is a critical component of the tooth anchored to surrounding alveolar bones. Tooth root formation is driven by cells in the apical papilla (AP) that generate new dentin-forming odontoblasts at the root-forming front. Mesenchymal stem cells
Mizuki Nagata, Gaurav T. Gadhvi, Taishi Komori, Yuki Arai, Hiroaki Manabe, Angel Ka Yan Chu, Ramandeep Kaur, Meer Ali, Yuntao Yang, Chiaki Tsutsumi-Arai, Yuta Nakai, Yuki Matsushita, Nicha Tokavanich, W. Jim Zheng, Joshua D. Welch, Noriaki Ono, Wanida Ono   +16 more
doaj   +2 more sources

Histatin-1 promotes the expression of markers associated with odontoblastic differentiation in the dental pulp and apical papilla [PDF]

Scientific Reports
Complex tooth injuries, including dental caries, require the reestablishment of tissue architecture and functionality through the regeneration of cellular populations that enable tertiary dentin formation and the reestablishment of vascular and neural ...
Patricio Silva, Mauricio Garrido, Héctor A. Tapia, Diego Ormeño, Sebastián Benito, Jorge Segura, Floris J. Bikker, Kamran Nazmi, Elías Utreras, Mónica Cáceres, Vicente A. Torres   +10 more
doaj   +2 more sources

Expression of Toll-like Receptors in Stem Cells of the Apical Papilla and Its Implication for Regenerative Endodontics [PDF]

Cells, 2023
Regenerative therapies to replace cells and tissues damaged due to trauma and dental infections require temporal and spatial controlled recruitment and the differentiation of progenitor/stem cells.
Koyo Takimoto, Matthias Widbiller, Anibal Diogenes   +2 more
doaj   +2 more sources

m⁶A-Modified GATA2 Enhances Odontogenic Differentiation in Stem Cells from the Apical Papilla. [PDF]

Int J Mol Sci
Epigenetic modifications play a crucial role in regulating stem cell differentiation. Among these, N6-methyladenosine (m6A) modification significantly impacts mRNA stability and translation. However, its role in dental stem cell differentiation remains largely unexplored.
Yang H, Yuan F, Song J, Huang Y, Shan Z, Fan Z.   +5 more
europepmc   +3 more sources

KDM6B Negatively Regulates the Neurogenesis Potential of Apical Papilla Stem Cells via HES1. [PDF]

Int J Mol Sci, 2023
Stem cells from the apical papilla (SCAPs) are used to regulate the microenvironment of nerve defects. KDM6B, which functions as an H3K27me3 demethylase, is known to play a crucial role in neurogenesis. However, the mechanism by which KDM6B influences the neurogenesis potential of SCAPs remains unclear.
Zhang C, Ye W, Zhao M, Long L, Xia D, Fan Z.   +5 more
europepmc   +3 more sources