Results 1 to 10 of about 11,276 (233)
Structural basis for sterol sensing by Scap and Insig [PDF]
Cell Reports, 2021 Summary: The sterol regulatory element-binding protein (SREBP) pathway monitors the cellular cholesterol level through sterol-regulated association between the SREBP cleavage-activating protein (Scap) and the insulin-induced gene (Insig).
Pingping Cao, Chuangye Yan, Hongwu Qian
exaly +5 more sources
Retrospective on Cholesterol Homeostasis: The Central Role of Scap [PDF]
Annual Review of Biochemistry, 2018 Scap is a polytopic membrane protein that functions as a molecular machine to control the cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory discovered Scap, we have learned how it binds sterol regulatory element-binding proteins (SREBPs) and transports them from the endoplasmic reticulum (ER) to the Golgi for ...
Michael Stuart Brown +2 more
exaly +4 more sources
The cellular function of SCAP in metabolic signaling [PDF]
Experimental and Molecular Medicine, 2020 Metabolic diseases: blocking fat and cholesterol production The complex cellular functions of a membrane protein that influences fat and cholesterol levels have been reviewed by researchers in South Korea.
Sun Hee Lee, Jae-Ho Lee, Seung-Soon Im
doaj +3 more sources
Journal of Advanced Research, 2023 Introduction: Sterol regulatory element binding protein (SREBP) cleavage-associating protein (SCAP) is a sterol-regulated escort protein that translocates SREBPs from the endoplasmic reticulum to the Golgi apparatus, thereby activating lipid metabolism ...
Seung-Soon Im, Byung-Chul Oh
exaly +3 more sources
Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner [PDF]
Journal of Lipid Research, 2016 Sterol regulatory element-binding protein (SREBP) transcription factors are central regulators of cellular lipid homeostasis and activate expression of genes required for fatty acid, triglyceride, and cholesterol synthesis and uptake.
Wei Shao (邵威) +2 more
doaj +3 more sources
Effects of stem cells derived from the apical papilla (SCAP) on dental pulp outcomes: the influence of docosahexaenoic acid (DHA) [PDF]
Regenerative TherapyIntroduction: This study investigated the effects of conditioned medium from stem cells of the apical papilla (CM-SCAP) modulated by the pro-resolution mediator docosahexaenoic acid (DHA), with or without a hydroxyapatite/tricalcium phosphate (HATCP ...
Natália D. Pacheco +5 more
doaj +2 more sources
EVALUATION OF THE ADHESION AND MORPHOLOGY OF STEM CELLS FROM APICAL PAPILLA IN DIRECT CONTACT WITH MTA AND BIODENTINE [PDF]
Journal of IMAB, 2022 Purpose: To investigate the use of tricalcium silicate cement Biodentine as an alternative to MTA in regenerative endodontic procedures by assessing the morphology and adhesion of stem cells from apical papilla in direct contact with these materials ...
Krasimir Hristov +3 more
doaj +1 more source
EFFECT OF CHEMICAL AND ORGANIC FERTILIZER ON THREE VARIETIES OF BROAD BEAN [PDF]
Mesopotamia Journal of Agriculture, 2019 The study was carried out in the field of vegetables Department of Horticulture and Land scap Design / Faculty of Agriculture and Forestry / University of Mosul / Iraq during the growth season 2017-2018 to study effect of two factors: the first three ...
Walled B. AL-Deen Al-Leela +3 more
doaj +1 more source
BMC Pulmonary Medicine, 2023 Background Severe community-acquired pneumonia (SCAP) is one of the most common critical and acute diseases in the respiratory and acute medicine department.
Pengtao Su +3 more
doaj +1 more source
MiR-181b serves as diagnosis and prognosis biomarker in severe community-acquired pneumonia
Genetics and Molecular Biology, 2021 Severe community-acquired pneumonia (SCAP) is a common critical disease in the intensive care unit (ICU). This study aims to evaluate the clinical significance of miR-181b in SCAP, which has been revealed to be dysregulated in acute respiratory distress ...
Qiaolian Li, Tingting Wu, Song Li
doaj +1 more source