Results 41 to 50 of about 8,394 (182)

SCAP, an ER Sensor that Regulates Cell Cholesterol [PDF]

Developmental Cell, 2002
Cells keep their cholesterol in balance by sensing its level in the endoplasmic reticulum and transducing this information into the expression of multiple homeostatic genes. Two recent papers from the Brown and Goldstein laboratory provide important new insights into how an integral ER protein, SCAP, mediates this process.
Steck, Theodore L., Lange, Yvonne
openaire   +2 more sources

Scaps: type-directed API search for Scala [PDF]

Proceedings of the 2016 7th ACM SIGPLAN Symposium on Scala, 2016
Type-directed API search, using queries composed of both keywords and type signatures to retrieve definitions from APIs, are popular in the functional programming community. This search technique allows programmers to easily navigate complex and large APIs in order to find the definitions they are interested in.
Lukas Wegmann, Farhad Mehta, Peter Sommerlad, Mirko Stocker   +3 more
openaire   +1 more source

Scap-Exo-Mediated Dspp Mrna Delivery Induces Bmmscs Specific Dentinogenesis

International Dental Journal
Aim or purpose: To investigate the use of exosomes derived from stem cells from apical papilla (SCAP-Exo) to deliver dentin sialophosphoprotein (DSPP) mRNA, promoting odontogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs) and ...
Xueying Zhuang, Xu Chen
doaj   +1 more source

Metodologije spremljanja cen gozdnih lesnih sortimentov v izbranih državah

Acta Silvae et Ligni, 2022
Monitoring the development of forest wood assortment prices is important for successful strategic planning, especially in the event of sudden changes in the wood market and in the implementation of trade policy.
Špela Ščap, Janez Zafran
doaj   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Dry‑Contact Trimming for All‑Perovskite Tandem Solar Cells via Solid‑Solution Homogenization

Advanced Energy Materials, EarlyView.
Narrow‐bandgap Sn–Pb perovskites are promising bottom absorbers for all‐perovskite tandems but suffer from Sn‐rich surfaces and depth‐dependent lattice/compositional inhomogeneity. Layered‐perovskite‐assisted dry‐contact trimming removes Sn‐rich surface species and reconfigures the Sn–Pb absorber, enabling efficient charge collection, reduced voltage ...
Woocheol Han, Hyojin Hong, Chan Young Kim, Chan Ho Shin, Sung Yong Kim, So Eun Shin, Minhyeok Park, Giseon Yu, Sohyun Kang, Seungmin Lee, Jun Hong Noh   +10 more
wiley   +1 more source

SCAP - a Shaped Charge Analysis Program: user's manual for SCAP 1. 0 [PDF]

, 1985
The basic modeling and format for a shaped charge analysis program, SCAP, is described. The code models the motion of liner elements due to explosive loading, jet formation, jet breakup and target penetration through application of a series of analytical approximations.
openaire   +2 more sources

Smart Exploration of Perovskite Photovoltaics: From AI Driven Discovery to Autonomous Laboratories

Advanced Energy Materials, EarlyView.
In this review, we summarize the fundamentals of AI in automated materials science, and review AI applications in perovskite solar cells. Then, we sum up recent progress in AI‐guided manufacturing optimization, and highlight AI‐driven high‐throughput and autonomous laboratories.
Wenning Chen, Zheyu Zhang, Kelvian T. Mularso, Bonghyun Jo, Hyun Suk Jung   +4 more
wiley   +1 more source

miR-486-5p predicted adverse outcomes of SCAP and regulated K. pneumonia infection via FOXO1

BMC Immunology
Purpose Severe community-acquired pneumonia (SCAP) is a common respiratory system disease with rapid development and high mortality. Exploring effective biomarkers for early detection and development prediction of SCAP is of urgent need.
Qianqi Jin, Chuanlan Liu, Yan Cao, Feiyan Wang   +3 more
doaj   +1 more source