Structural basis for sterol sensing by Scap and Insig [PDF]
Cell Reports, 2021 Summary: The sterol regulatory element-binding protein (SREBP) pathway monitors the cellular cholesterol level through sterol-regulated association between the SREBP cleavage-activating protein (Scap) and the insulin-induced gene (Insig).
Renhong Yan, Pingping Cao, Wenqi Song
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The cellular function of SCAP in metabolic signaling [PDF]
Experimental and Molecular Medicine, 2020 Metabolic diseases: blocking fat and cholesterol production The complex cellular functions of a membrane protein that influences fat and cholesterol levels have been reviewed by researchers in South Korea.
Sun Hee Lee, Jae-Ho Lee, Seung-Soon Im
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Effects of stem cells derived from the apical papilla (SCAP) on dental pulp outcomes: the influence of docosahexaenoic acid (DHA) [PDF]
Regenerative TherapyIntroduction: This study investigated the effects of conditioned medium from stem cells of the apical papilla (CM-SCAP) modulated by the pro-resolution mediator docosahexaenoic acid (DHA), with or without a hydroxyapatite/tricalcium phosphate (HATCP ...
Natália D. Pacheco +5 more
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Competition between a transmembrane helix on Scap and a membrane cholesterol regulates Scap–Insig interaction and SREBP activation [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaCholesterol homeostasis in mammalian cells relies on the interaction between two endoplasmic reticulum (ER) sterol-sensing membrane proteins, Scap and Insig. Their interaction regulates activation of transcription factors called sterol regulatory element–binding proteins (SREBPs) that control genes for cholesterol biosynthesis and uptake.
Daniel L Kober +2 more
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Journal of Advanced Research, 2023 Introduction: Sterol regulatory element binding protein (SREBP) cleavage-associating protein (SCAP) is a sterol-regulated escort protein that translocates SREBPs from the endoplasmic reticulum to the Golgi apparatus, thereby activating lipid metabolism ...
Byung-Chul Oh, Seung-Soon Im
exaly +3 more sources
Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner [PDF]
Journal of Lipid Research, 2016 Sterol regulatory element-binding protein (SREBP) transcription factors are central regulators of cellular lipid homeostasis and activate expression of genes required for fatty acid, triglyceride, and cholesterol synthesis and uptake.
Wei Shao (邵威) +2 more
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SLIT3: a novel regulator of odontogenic differentiation through Akt/GSK3β/β-catenin signaling pathway [PDF]
International Journal of Oral ScienceThe odontogenic differentiation of Stem Cells from Apical Papilla (SCAP) are governed by various extracellular matrix proteins, playing a crucial role in dentin formation and regeneration.
Lingyu Jiang +8 more
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Cholesterol-driven pathological astrocytic responses in diabetes-associated cognitive impairment through astrocytic SCAP accumulation and NF-κB–C3 signaling modulation [PDF]
Experimental and Molecular MedicineThe diabetic environment, characterized by hyperglycemia, advanced glycation end products and cerebral insulin resistance, triggers pathological astrocytic responses that contribute to cognitive decline in diabetes-associated cognitive impairment ...
Tong Niu +8 more
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Identification of subtypes and construction of a predictive model for novel subtypes in severe community-acquired pneumonia based on clinical metagenomics: a multicenter, retrospective cohort study [PDF]
Frontiers in Cellular and Infection MicrobiologyObjectiveIt is well recognized that high heterogeneity represents a key driver of the elevated mortality in severe community-acquired pneumonia (sCAP).
Shiyi Chen +15 more
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EVALUATION OF THE ADHESION AND MORPHOLOGY OF STEM CELLS FROM APICAL PAPILLA IN DIRECT CONTACT WITH MTA AND BIODENTINE [PDF]
Journal of IMAB, 2022 Purpose: To investigate the use of tricalcium silicate cement Biodentine as an alternative to MTA in regenerative endodontic procedures by assessing the morphology and adhesion of stem cells from apical papilla in direct contact with these materials ...
Krasimir Hristov +3 more
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