Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81 [PDF]
Stem Cell Research & TherapyBackground The cartilage tissue regeneration mediated with mesenchymal stem cells (MSCs) is considered as a viable strategy for temporomandibular joint osteoarthritis (TMJOA). Betaine has been confirmed to modulate the multidirectional differentiation of
Meiyue Wang +10 more
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Inhibition of miR-615-3p enhances dentinogenesis in scaps via PVT1-mediated mitochondrial regulation [PDF]
Stem Cell Research & TherapyBackground Mesenchymal stem cells (MSCs) are critical for dental tissue regeneration, yet their differentiation potential is tightly regulated by microRNAs (miRNAs).
Haoqing Yang +5 more
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Roles of basic fibroblast growth factor, stem cells from dental pulp and apical papilla in the repair and regeneration of dental pulp and other tissues/organs [PDF]
Journal of Dental SciencesCurrently, the concept of regeneration and regenerative therapies are already being applied clinically to treat pulpal and periodontal diseases, as well as to repair and regenerate systemic organs and tissues.
Pin-Hsuan Wu +5 more
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Research progress in heterogeneity of dental mesenchymal stem cells [PDF]
International Journal of Oral ScienceDental tissues development involves two distinct cell lineages: mesenchymal cells (derived from the cranial neural crest) and epithelial cells (derived from oral ectoderm and pharyngeal epithelium).
Hanqi Fu +9 more
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Sustained Mg/Sr ion delivery from injectable silk fibroin hydrogels drives SCAP osteogenic differentiation [PDF]
iScienceSummary: This study highlights the biomedical relevance of injectable TS (tannic acid-silk fibroin)-Mg/Sr hydrogels in alveolar bone repair, particularly their prospective role as carriers for stem cells from the apical papilla (SCAPs) in tissue ...
Chen Chen +7 more
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The combination of odontogenic stem cells and mandibular advancement promotes the length of the mandible in adult rats by facilitating the development of condylar cartilage [PDF]
Stem Cell Research & TherapyBackground Mandibular retraction is a prevalent dental and maxillofacial deformity that negatively affects patients' functional health and facial aesthetics.
Xin Cheng +6 more
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A Biomimetic Approach to Diode Laser Use in Endodontic Treatment of Immature Teeth: Thermal, Structural, and Biological Analysis [PDF]
BiomimeticsThe root walls of immature permanent teeth are often weak, thin, and short, making regenerative endodontic treatment (RET) necessary. The goal of RET is to create a favorable environment for further root development.
Dijana D. Mitic +6 more
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Exosomes derived from apical papilla stem cells improve NASH by regulating fatty acid metabolism and reducing inflammation [PDF]
Molecular MedicineBackground Apical papilla stem cells (SCAPs) exhibit significant potential for tissue repair, characterized by their anti-inflammatory and pro-angiogenic properties.
Yifei Nie +10 more
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Journal of Oral Biology and Craniofacial Research, 2021 Although dental pulp and apical papilla are originated from neural crest cells, these tissues exhibit distinct characteristics. Notch signaling is one of the known signaling pathways regulating stemness and behaviors of stem cells.
Damrong Damrongsri +4 more
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Effect of Long-Term Cryopreservation on the Stemness of Stem Cells of Apical Papilla
International Journal of Dentistry, 2022 Stem cells of apical papilla (SCAPs) are considered a subpopulation of dental stem cells with unique properties. They originate from a developing tissue, the apical papilla of developing teeth, a characteristic that enhances their stemness.
Anna Digka +3 more
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