Results 251 to 260 of about 862,152 (305)

Metal‐Catalyzed Cross‐Coupling for the Synthesis of β‐Lactam Drugs and Related Chemical Probes

ChemMedChem, EarlyView.
This review focus on the use of transition metal cross‐coupling strategies for the synthesis of beta‐lactam derivatives. This manuscript encompasses the seminal studies for the synthesis of antibiotics up to the current need of accessing specific probes that are crucial for the detection of resistances.
Jules Bresson, Katie Burke, Mélanie Ethève‐Quelquejeu, Laura Iannazzo, Kevin Cariou   +4 more
wiley   +1 more source

Class B Scavenger Receptor CD36 as a Potential Therapeutic Target in Inflammation Induced by Danger-Associated Molecular Patterns. [PDF]

Cells
Baranova IN, Bocharov AV, Vishnyakova TG, Chen Z, Ke Y, Birukova AA, Yuen PST, Tsuji T, Star RA, Birukov KG, Patterson AP, Eggerman TL.   +11 more
europepmc   +1 more source

β‐Glucuronidase‐Responsive Albumin‐Binding Prodrug of Colchicine‐Site Binders for Selective Cancer Therapy

ChemMedChem, EarlyView.
This study presents a β‐glucuronidase‐responsive albumin‐binding prodrug enabling the selective release within the tumor microenvironment of an Isocombretastatin A‐4 analog. In triple‐negative breast cancer (TNBC) mouse models, this prodrug demonstrated significant tumor growth inhibition, highlighting potential for enhanced therapeutic selectivity and
Alexandra Bordes, Isabelle Opalinski, Fabien Thoreau, Olivier Provot, Abdallah Hamze, Mouad Alami, Sébastien Papot   +6 more
wiley   +1 more source

Impacts of <i>CD36</i> Variants on Plasma Lipid Levels and the Risk of Early-Onset Coronary Artery Disease: A Systematic Review and Meta-Analysis. [PDF]

Cardiovasc Ther
Luo Z, Lv L.
europepmc   +1 more source

Systematic Review on 1,2,3‐Oxadiazoles, 1,2,4‐Oxadiazoles, and 1,2,5‐Oxadiazoles in the Antimycobacterial Drug Discovery

ChemMedChem, EarlyView.
The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley   +1 more source

CXCL16 knockout inhibit asthma airway inflammation by suppressing H2-DM molecular mediated antigen presentation. [PDF]

Cell Death Discov
Liu TT, Zhang Z, Deng J, Shi CY, Zheng S, Jia LX, Du J, Piao C.   +7 more
europepmc   +1 more source

Advances in Diclofenac Derivatives: Exploring Carborane‐Substituted N‐Methyl and Nitrile Analogs for Anticancer Therapy

ChemMedChem, EarlyView.
By N‐methylation, the intramolecular lactam formation in carborane‐substituted diclofenac analogs is prevented, yielding a series of open‐chain derivatives alongside with their phenyl analogs exhibiting anticancer activity and thus offering a promising avenue for future drug development. This study explores the anticancer potential of N‐methylated open‐
Christoph Selg, Robert Schuster, Aleksandr Kazimir, Peter Lönnecke, Mara Wolniewicz, Jonas Schädlich, Markus Laube, Jens Pietzsch, Vuk Gordić, Tamara Krajnović, Sanja Mijatović, Danijela Maksimović‐Ivanić, Evamarie Hey‐Hawkins   +12 more
wiley   +1 more source

Sustainable Synthesis, Characterization, Cellular Effects of Gold Nanoparticles and Their Applications as Therapeutics in Cancer Therapy

ChemPlusChem, Accepted Article.
In recent years, gold nanoparticles (AuNPs) have attracted much attention due to their extensive applications in fields such as biomedicine, electronics, catalysis, and environmental science. However, traditional chemical methods for AuNPs synthesis present certain challenges, such as the use of harsh chemicals and high energy consumption.
Youfeng Yue, Akihiro Moriyama, Marie Mita, Yue Yu   +3 more
wiley   +1 more source

Rethinking Chlorine: Essential Chemical or Replaceable Risk?

ChemSusChem, Accepted Article.
This review critically examines the dual nature of chlorine as both an indispensable base chemical and a potential risk. Chlorine and its by‐product hydrogen chloride play essential roles in the production of pharmaceuticals, plastics, agrochemicals, and disinfectants.
Johannes Schwan, Merlin Kleoff, Gesa H. Dreyhsig, Patrick Voßnacker, Traute Fiedler, Marian Rosental, Sebastian Riedel   +6 more
wiley   +1 more source

Structure of scavenger receptor SCARF1 and its interaction with lipoproteins. [PDF]

Elife
Wang Y, Xu F, Li G, Cheng C, Yu B, Zhang Z, Kong D, Chen F, Liu Y, Fang Z, Cao L, Yu Y, Gu Y, He Y.   +13 more
europepmc   +1 more source