Results 31 to 40 of about 56,399 (161)

High density lipoprotein metabolism in low density lipoprotein receptor-deficient mice1[S]

Journal of Lipid Research, 2014
The LDL receptor (LDLR) and scavenger receptor class B type I (SR-BI) play physiological roles in LDL and HDL metabolism in vivo. In this study, we explored HDL metabolism in LDLR-deficient mice in comparison with WT littermates.
Franz Rinninger, Markus Heine, Roshni Singaraja, Michael Hayden, May Brundert, Rajasekhar Ramakrishnan, Joerg Heeren   +6 more
doaj   +1 more source

The hepatoadrenal syndrome: A common yet unrecognized clinical condition [PDF]

, 2005
Objective: Adrenal failure is common in critically ill patients, particularly those with sepsis. As liver failure and sepsis are both associated with increased circulating levels of endotoxin and proinflammatory mediators and reduced levels of apoprotein-
Acton, Ali, Annane, Annane, Baranova, Beishuizen, Borkowski, Calco, Cicognani, Cooper, Darlington, Davies, de la Llera-Moya, Dimopoulou, Eisenberg, Ettinger, Gordon, Hamrahian, Harry, Hinshaw, Jaattela, Kilger, Liu, Liu, Liu, Liu, Loriaux, Marik, Marik, Marik, Marik, Marik, McDonald, Melby, Miyata, Molijn, Molijn, Mookerjee, Paul E. Marik, Rasaratnam, Rivers, Scammell, Singh, Sun, Thomas E. Starzl, Timothy Gayowski, van der Voort, van Leeuwen, Vishnyakova, Yaguchi, Yokoyama, Yokoyama   +51 more
core   +1 more source

Localization of the PE methylation pathway and SR-BI to the canalicular membrane

Journal of Lipid Research, 2003
To better understand the regulation of biliary phospholipid and cholesterol excretion, canalicular membranes were isolated from the livers of C57BL/6J mice and abundant proteins separated by SDS-PAGE and identified by matrix-assisted laser desorption ...
Ephraim Sehayek, Rong Wang, Jennie G. Ono, Vadim S. Zinchuk, Elizabeth M. Duncan, Sarah Shefer, Dennis E. Vance, Meenakshisundaram Ananthanarayanan, Brian T. Chait, Jan L. Breslow   +9 more
doaj   +1 more source

A gut feeling for drugs that have metabolic benefits

Nature Communications, 2023
Resveratrol (REV) is a natural polyphenol with anti-obesity effects. However, the mechanisms remain unclear due to its low bioavailability and the lack of defined membrane-bound or nuclear receptors.
Eryun Zhang, Alon Agua, Wendong Huang
doaj   +1 more source

Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice

Journal of Lipid Research, 2005
The function of scavenger receptor class B type I (SR-BI) in mediating the selective uptake of HDL cholesteryl esters is well established. In SR-BI-deficient mice, we recently observed a delayed postprandial triglyceride (TG) response, suggesting an ...
Ruud Out, Menno Hoekstra, Saskia C.A. de Jager, Paula de Vos, Deneys R. van der Westhuyzen, Nancy R. Webb, Miranda Van Eck, Eric A.L. Biessen, Theo J.C. Van Berkel   +8 more
doaj   +1 more source

Targeting neuroinflammation in Alzheimer’s disease [PDF]

, 2016
Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately 60%–80% of all dementia cases. Given this evidence, it is clear dementia represents one
Bronzuoli, MARIA ROSANNA, Iacomino, Aniello, Scuderi, Caterina, Steardo, Luca   +3 more
core   +1 more source

Regulation and splicing of scavenger receptor class B type I in human macrophages and atherosclerotic plaques

BMC Cardiovascular Disorders, 2005
Background The protective role of high-density lipoprotein (HDL) in the cardiovascular system is related to its role in the reverse transport of cholesterol from the arterial wall to the liver for subsequent excretion via the bile.
Fagerberg Björn, Thelle Dag S, Mattsson-Hulten Lillemor, Stemme Veronika, Ohlsson Bertil G, Hägg Daniel A, Snäckestrand Magnus SC, Englund Mikael CO, Svensson Per-Arne, Wiklund Olov, Carlsson Lena MS, Carlsson Björn   +11 more
doaj   +1 more source

Three polymethoxyflavones from the peel of Citrus reticulata “Chachi” inhibits oxidized low-density lipoprotein-induced macrophage-derived foam cell formation

Frontiers in Cardiovascular Medicine, 2022
Foam cell formation is the hallmark of the development and progression of atherosclerosis. The aim of this study was to investigate the regulatory effects of three polymethoxyflavones (PMFs), namely, tangeretin (TAN), 5,6,7,3′,4′,5′-hexamethoxyflavone ...
Pu-Lin Liang, Qian-Wen Liang, Pei-Wen He, Xue-Lian Chen, Ya Xu, Hai-Sheng Tu, Liang Zhang, Xiao-Hui Qiu, Xiao-Hui Qiu, Jing Zhang, Zhi-Hai Huang, Wen Xu, Wen Xu   +12 more
doaj   +1 more source

Primary hepatocytes as targets for hepatitis C virus replication [PDF]

, 2008
Much of our current understanding of hepatitis C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines.
Agnello, Andre, Andreo, Bartenschlager, Bartosch, Bartosch, Bartosch, Basu, Bertaux, Castet, Catanese, Chang, Cocquerel, Codran, Decaens, Diaz, Dreux, Evans, Flint, Fournier, Furuse, Gastaminza, Grove, Harder, Harris, Hsu, Huang, Kanda, Kapadia, Krieger, Lazaro, Levy, Lindenbach, Lindenbach, Maillard, Martin, McCaughan, Mee, Meertens, Mercer, Meuleman, Meunier, Moghe, Molina, Molina, Morikawa, Nielsen, Nielsen, Olenina, Pileri, Prince, Reynolds, Scarselli, Silver, Thomssen, Timpe, Vinken, Voisset, Wakita, Wang, Wunschmann, Yang, Zeisel, Zhang, Zheng, Zhong   +65 more
core   +2 more sources

Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts

Journal of Lipid Research, 2006
Previous studies have suggested that HDL retroendocytosis may play a role in scavenger receptor class B type I (SR-BI)-dependent selective lipid uptake in a cell-specific manner.
Bing Sun, Erik R.M. Eckhardt, Shoba Shetty, Deneys R. van der Westhuyzen, Nancy R. Webb   +4 more
doaj   +1 more source