Results 51 to 60 of about 56,399 (161)

Macrophage autophagy in atherosclerosis [PDF]

, 2013
Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Carnuccio, R., Grassia, G., Ialenti, A., Maffia, P., Maiuri, M.C., Platt, A.   +5 more
core   +2 more sources

Altered adrenal gland cholesterol metabolism in the apoE-deficient mouse

Journal of Lipid Research, 2002
Previous studies suggest the hypothesis that apoE produced by adrenocortical cells modulates cellular cholesterol metabolism to enhance the storage of esterified cholesterol (4444411) at the expense of cholesterol delivery to the steroidogenic pathway ...
Fayanne E. Thorngate, Penelope A. Strockbine, Sandra K. Erickson, David L. Williams   +3 more
doaj   +1 more source

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]

, 2009
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni, A Duka, A Patsialou, A Rigotti, A Walsh, AP Feinberg, B Staels, B Staels, B Staels, B Staels, B Staels, B Staels, BN Finck, CW Miller, D Arsenijevic, D Lan, D Sanoudou, D Sanoudou, D Sanoudou, EM Rubin, ES Cathcart, F Yadetie, G Fredrikson, G Martin, H Duez, H Samyn, HB Rubins, HY Kan, J Karbowska, J Lin, J St Pierre, JC Fruchart, JD Brunzell, JJ Lehman, JK Reddy, JL Goldstein, JM Huss, JM Huss, JP Desager, K C Hayes, K Drosatos, K Motojima, K Schoonjans, K Schoonjans, KE Kypreos, KE Kypreos, KS Frederiksen, L Berthou, LA Pennacchio, LJ Kelly, M Bouly, MB Eisen, MC Hunt, MJ Holness, N Hennuyer, N Vu-Dac, N Vu-Dac, N Vu-Dac, N Vu-Dac, NF Cariello, P Puigserver, Q Guo, R Sladek, RB Vega, RL Jacobs, SA Greenberg, SN Schreiber, V Beisvag, V Giguere, V I Zannis, V Litvak, VG Tusher, VI Zannis, VI Zannis, VI Zannis, WC Roberts, X Prieur, Y Kamei, Y Nagai, Z Wu   +79 more
core   +3 more sources

Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI

Journal of Lipid Research, 2007
Modified forms of LDL, including oxidized low density lipoprotein (OxLDL), contribute to macrophage lipid accumulation in the vessel wall. Despite the pathophysiological importance of uptake pathways for OxLDL, the molecular details of OxLDL endocytosis ...
Bing Sun, Boris B. Boyanovsky, Margery A. Connelly, Preetha Shridas, Deneys R. van der Westhuyzen, Nancy R. Webb   +5 more
doaj   +1 more source

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease [PDF]

, 2017
Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a diverse variety of ligands ...
Acton, Acton, Aziz-Seible, Bartolome, Benita McVicker, Bridge, Casey, Chen, Cong, Cynthia L. Baldwin, Dachy, Dawn M. E. Bowdish, Debanne, Dzwonek, Endemann, Fogelman, Geoffrey M. Thiele, Guy, Janice C. Telfer, Joachim Herz, John Loike, Joseph El Khoury, Krieger, Kurt Drickamer, Lester Kobzik, Maria Febbraio, McVicker, McVicker, McVicker, Mercy R. PrabhuDas, Monty Krieger, Murphy, Newton, Paul L. Bollyky, Pike, Robert C. Speth, Ruppert, Samuel D. Wright, Samuel Silverstein, Soren K. Moestrup, Steven R. Post, Stockert, Tatsuya Sawamura, Terry K. Means, van der Laan, Wilkinson, Xiang-Yang Wang   +46 more
core   +1 more source

Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages

FEBS Open Bio, 2021
Apolipoprotein M (ApoM) exhibits various anti‐atherosclerotic functions as a component of high‐density lipoprotein (HDL) particles. Scavenger receptor class B type I (SR‐BI) is a classic HDL receptor that mediates selective cholesterol uptake and ...
Shuang Yao, Fan Zheng, Yang Yu, Yuxia Zhan, Ning Xu, Guanghua Luo, Lu Zheng   +6 more
doaj   +1 more source

Regulation of scavenger receptor class B type I in hamster liver and Hep3B cells by endotoxin and cytokines

Journal of Lipid Research, 2001
Multiple changes in HDL metabolism occur during infection and inflammation that could potentially impair the antiatherogenic functions of HDL. Scavenger receptor class B type I (SR-BI) promotes cholesterol efflux from peripheral cells and mediates ...
Weerapan Khovidhunkit, Arthur H. Moser, Judy K. Shigenaga, Carl Grunfeld, Kenneth R. Feingold   +4 more
doaj   +1 more source

The microglial "activation" continuum: from innate to adaptive responses [PDF]

, 2005
Microglia are innate immune cells of myeloid origin that take up residence in the central nervous system (CNS) during embryogenesis. While classically regarded as macrophage-like cells, it is becoming increasingly clear that reactive microglia play more ...
Nikolic, Veljko, Tan, Jun, Town, Terrence   +2 more
core   +3 more sources

HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

Journal of Lipid Research, 2000
During inflammatory states plasma levels of high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) are reduced. Secretory group IIa phospholipase A2 (sPLA2) is a cytokine-induced acute-phase enzyme associated with HDL. Transgenic mice
Frederick C. de Beer, Patrice M. Connell, J. Yu, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen   +5 more
doaj   +1 more source

ROLE OF SCAVENGER RECEPTOR CLASS B TYPE I IN THYMOPOIESIS [PDF]

, 2014
T cells, which constitute an essential arm in the adaptive immunity, complete their development in the thymus through a process called thymopoiesis. However, thymic involution can be induced by a couple of factors, which impairs T cell functions and is ...
Zheng, Zhong
core   +1 more source