Results 71 to 80 of about 38,420,644 (271)

Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems [PDF]

Journal of Clinical Investigation, 2001
Scavenger receptors (SRs) are defined as cell surface membrane proteins that bind chemically modified lipoproteins, such as acetylated LDL (AcLDL) and oxidized LDL (OxLDL), and often many other types of ligands (1–3). Initially, scavenger receptor activity was identified as “AcLDL receptor activity” by Brown, Goldstein, and colleagues (2), who were ...
openaire   +2 more sources

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Role Analysis of the scarb1 Gene in the Pigmentation of Neocaridina denticulata sinensis

Animals
Body color is a key economic trait for Neocaridina denticulata sinensis, an important ornamental shrimp. Scarb1 may be an important mediator of astaxanthin uptake, changing the shrimp’s body color.
Lili Zhang, Guodong Wang, Haifan Li, Tanjun Zhao   +3 more
doaj   +1 more source

Identification of Scavenger Receptor Class B Type I in the Hepatocytes of Hypercholesterolemic Rats

Microscopy and Microanalysis, 2001
Abstract The levels of plasma high density lipoproteins (HDL) are inversely related to the incidence of atherosclerosis and coronary heart disease. This protective effect of HDL is thought to be involved in the reverse transport of cholesterol from peripheral tissue to the liver. The scavenger receptor class B type 1 (SR-BI) is the first
J Y Wang, Y W Lee, H Y Hsiao, W T Chao, V C Yang   +4 more
openaire   +1 more source

Upscaling the Fabrication of Rod‐Shaped Microgels: A Microfluidic Method Combining Step‐Emulsification With Consecutive Droplet Confinement in Parallelized Microchannels

Advanced Materials, EarlyView.
A microfluidic method is presented which enables parallelized fabrication of rod‐shaped microgels, based on step‐emulsification (SE) droplet generation and subsequent droplet distribution and confinement, combined in a single device. Microgel rods are fabricated in parallel at different flow rates based on two light‐mediated crosslinking chemistries ...
Matthias Mork, Ninon Möhl, Greta Romahn, Laura Klasen, Cédric Bergerbit, Laura De Laporte   +5 more
wiley   +1 more source

DataSheet1_Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-1 expression in coronary artery endothelium.PDF

, 2023
High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL
Melissa E. MacDonald (14392422), Ting Xiong (1302621), Pardh Chivukula (14392419), Samuel K. Lee (14392425), Suleiman A. Igdoura (14392431), Bernardo L. Trigatti (445281), Richard C. Austin (14392428), Omid Dadoo (445278), Mark T. Fuller (14392416)   +8 more
core   +1 more source

Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI

Journal of Lipid Research, 2006
Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis.
May Brundert, Joerg Heeren, Mukaddes Bahar-Bayansar, Anne Ewert, Kathryn J. Moore, Franz Rinninger   +5 more
doaj   +1 more source

Multimodal Locomotion in Insect‐Inspired Microrobots: A Review of Strategies for Aerial, Surface, Aquatic, and Interfacial Motion

Advanced Robotics Research, EarlyView.
This review identifies key design considerations for insect‐inspired microrobots capable of multimodal locomotion. To draw inspiration, biological and robotic strategies for moving in air, on water surfaces, and underwater are examined, along with approaches for crossing the air–water interface.
Mija Jovchevska, Kaushik Jayaram, Nicole Xu   +2 more
wiley   +1 more source

E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I [PDF]

, 2005
Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium.
Marchetti, Barbara, O'Brien, P.M., Ashrafi, G. Hossein, Haghshenas, Mohammad R., O'Brien, Philippa M., Ashrafi, G.H., Haghshenas, M.R., Campo, M.S., Marchetti, B., Campo, M. Saveria   +9 more
core   +1 more source

Table1_Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-1 expression in coronary artery endothelium.XLSX

, 2023
High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL
Melissa E. MacDonald (14392422), Ting Xiong (1302621), Pardh Chivukula (14392419), Samuel K. Lee (14392425), Suleiman A. Igdoura (14392431), Bernardo L. Trigatti (445281), Richard C. Austin (14392428), Omid Dadoo (445278), Mark T. Fuller (14392416)   +8 more
core   +1 more source